eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
6/2016
vol. 33
 
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abstract:
Review paper

The possible role of diet in the pathogenesis of adult female acne

Krystyna Romańska-Gocka
,
Magdalena Woźniak
,
Elżbieta Kaczmarek-Skamira
,
Barbara Zegarska

Adv Dermatol Allergol 2016; XXXIII (6): 416-420
Online publish date: 2016/12/02
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Acne in adults is a chronic, increasingly common disease, especially among women. It differs in pathogenesis and clinical presentation from adolescent acne. Acne in adults is associated with Western diet, defined as high consumption of milk, high glycemic load and high calorie intake. Metabolic signals of this diet result in a significant increase in insulin/insulin growth factor 1 serum level and consequently in the molecular interplay of mammalian target of rapamycin complex 1 kinase (mTORC1)/forkhead box protein 1 (FoxO1) mediated nutrient signaling, leading to increased proliferation of keratinocytes, increased lipogenesis and sebum production and finally to aggravation of acne.
keywords:

female acne, diet, insulin growth factor 1, forkhead box protein 1, mammalian target of rapamycin complex 1 kinase

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