en POLSKI
eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank


 
1/2012
vol. 50
 
Share:
Share:
more
 
 
abstract:
Review paper

The role of T-lymphocytes in primary Sjögren syndrome

Żaneta Smoleńska
,
Justyna Pawłowska
,
Zbigniew Zdrojewski

Reumatologia 2012; 50, 1: 45–51
Online publish date: 2012/03/02
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Sjögren syndrome is a disease of the connective tissue with an autoimmune basis in the course of which chronic, progressing inflammatory processes in the lacrimal and salivary glands lead to the impediment of their secretory function, causing dryness of the eyes and the oral cavity; organ symptoms occur much more rarely. We can distinguish between primary and secondary Sjögren syndrome, which occur alongside other autoimmune diseases. Many cells of the immune system are involved in the not yet fully explored pathomechanism of Sjögren syndrome. Beyond doubt, type T lymphocytes play a significant role in the development of Sjögren syndrome, especially in local inflammation (Table I). Besides the cells of the immunological system, cytokines, chemotactic factors and adhesion molecules as well as apoptosis play an important role in the pathomechanism of the development of Sjögren syndrome. Acquiring precise understanding of the role of T lymphocytes is crucial for explaining the pathomechanism of this disease as well as for introducing more targeted and effective methods of therapy, including biological agents.
keywords:

Sjögren syndrome, T-lymphocytes, cytokines, apoptosis, inflammatory process, autoimmune process







Quick links
© 2022 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.