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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 38
Original paper

The role of family history and its influence on the onset time in female pattern hair loss

Adriana Łukasik
Karolina Kozicka
Agata Kłosowicz
Andrzej Jaworek
Anna Wojas-Pelc

Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland
Adv Dermatol Allergol 2021; XXXVIII (5): 815–818
Online publish date: 2020/11/13
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Androgenic alopecia is the most common cause of hair loss both in women and in men. It is a chronic disease and it progresses with time. The onset time and intensity vary depending on the geographical location, but the intensity always tends to increase with age [14]. The highest prevalence is noted in the Caucasian population (29–56% of patients older than 70) [24], while the lowest one is observed in the Asian population (12–25% of patients over 70) [1, 5, 6]. The prevalence of hair loss in the family is also significantly higher in the white population [7]. In a study conducted by Wang et al. in the Chinese population, family history was positive for 19.2% of female patients [5], while in a study carried out by Paik et al. in Korea, that value reached 45.2% [1].

It is presently believed that the mode of inheritance is polygenic and multifactorial, but it has not been thoroughly examined in women yet.

To arrive at a correct diagnosis and exclude other potential causes of hair loss, a thorough medical history should be taken, including the duration of symptoms, intensity of hair loss, currently taken medications and the applied treatments. A trichoscopic examination is presently the gold standard in diagnostics.


The aim of the study was to evaluate the inheritance pattern of female pattern hair loss (FPHL) in women from the Polish population and potential influence of a positive family history for its earlier onset.

Material and methods

We qualified 111 unrelated female patients for the study. They were treated in the Department of Dermatology in Krakow in 2018–2019, and diagnosed with female pattern hair loss based on the clinical picture and the trichoscopic examination. Trichoscopy was performed with a handheld dermoscope and videodermatoscope. The diagnosis of FPHL was based on the presence of 2 major criteria or 1 major and 2 minor criteria. Major criteria included an increased number of yellow dots (more than 4 yellow dots in the frontal area in 4 fields of vision at 70-fold magnification) and thin hairs, decreased average hair thickness in the frontal area and more than 10% of thin hairs (< 0.03 mm) in the frontal area. Minor criteria included an increased frontal area to occiput ratio of single-hair units (> 2 : 1), vellus hairs (> 1.5 : 1) and follicles with perifollicular discoloration (> 3 : 1) [8].

The control group included 129 women without hair thinning and with a negative history of pathological hair loss. Some patients in the control group were treated in the Department of Dermatology for other skin diseases which had no influence on hair loss. A detailed family history concerning hair loss, taking into account the patient’s grandparents, parents, siblings and offspring, was collected in both groups. The onset time of the first symptoms (hair loss or hair thinning) was also noted, as stated by the patients.

Statistical analysis

The data are presented as numbers of cases and proportions expressed in percentages. We compared the studied group with the control group with respect to the family history, using Pearson’s χ2 test, with Yates correction if the expected number of observations was less than five. A two-sided p-value of < 0.05 was considered significant. The Statistica 10 software (StatSoft Inc., Tulsa, Oklahoma) was used for the calculations.


The average age of patients was similar in both groups (47 in the control group, and 48.4 in the studied group).

The age distribution of FPHL patients in the study

The youngest FPHL patient was 17 years old, while the oldest one was 86. Patients aged 30–49 constituted the biggest group among the FPHL patients (49.5%). Table 1 shows the number of patients in the different age groups.

Table 1

Number of patients in the different age groups

Age of patientsNumber of FPHL patients (n = 111)

The role of family history

The family history of hair thinning in the conducted study was positive for 69 (62.2%) FPHL patients, and for 36 (27.9%) patients from the control group. A positive family history concerning more than one person in the family, taking into account three generations back, was established for 32 (28.8%) patients in the studied group, and only 4 (3.1%) patients in the healthy group (p < 0.0001) (Table 2 and Figure 1).

Table 2

A comparison of positive family histories with respect to selected family members for FPHL patients and women from the healthy group

Family historyFPHL group = 111 n (%)Control group = 129 n (%)P-value
Mother32 (28.8)5 (3.8)< 0.0001
Father34 (30.6)20 (15.5)0.005
Mother and maternal family36 (32.4)6 (4.6)< 0.0001
Father and paternal family31 (27.9)21 (16.3)0.046
Parent60 (54.0)25 (19.4)< 0.0001
Figure 1

A comparison of hair loss prevalence on the mother’s and father’s sides in the FPHL group and the control group


Patients in the control group did not mention hair loss in their grandparents. However, the family history was positive for the grandparents of 20 patients from the FPHL group (Figure 2).

Figure 2

The percentage distribution depending on a positive history on the mother’s and father’s sides


Family history and the age of onset

The earliest onset reported by a patient in our study was at the age of 12. In that case, the family history was positive for the mother, the father and all four grandparents, and hair loss intensity was assessed as very high. A positive family history of hair loss in grandparents was three times more frequent among patients with the onset before the age of 40 (15 vs. 5 patients).

However, no statistically significant influence of hair loss in the family history on an earlier onset of FPHL was observed for the other patients, especially those aged 17–39 (p = 0.6257) (Table 3).

Table 3

The onset time of hair loss symptoms in correlation with the family history

OnsetFamily history
12–2523 (20.7%)17 (73.9%)6 (26.1%)
26–3518 (16.2%)9 (50.0%)9 (50.0%)
36–4523 (20.7%)16 (69.6%)7 (30.4%)
46–5524 (21.6%)14 (58.3%)10 (41.7%)
56–6514 (12.6%)8 (57.1%)6 (42.9%)
66–809 (8.1%)5 (55.6%)4 (44.4%)


Hair loss in the family is of great significance for FPHL development.

Our study revealed hair loss in one parent in the case of 53% of patients, which is comparable with the results of a study involving 30 female patients, conducted by Tandon et al. in India [9], where hair loss in first-degree relatives was noted in 46% of patients, and a study by Paik et al. [1], where a positive family history concerned approximately 40–54% of female patients, especially for an early-onset FPHL. The present study reveals no relationship between a positive history and an earlier onset of the disease, except for 1 case in which a very early onset (the twelfth year of life) correlated with a strongly positive family history.

In a study carried out by Wei Siah et al., which involved a group of 210 female patients with FPHL, the family history was positive for 85% of the patients (51% on the father’s side, 20% on the mother’s side, and 24% on both sides). The history was negative in 14% of patients [10]. Smith and Wells also observed a higher prevalence of hair loss in first-degree male relatives of women with FPHL than in those of healthy women [11].

In our study, the family history was positive for 62% of patients with FPHL. The prevalence of hair loss in male- and female-line relatives was comparable, with a slight predominance of a positive history on the father’s side (34 vs. 32). A positive family history on the father’s side also prevailed in the control group.

Taking into account the hair loss prevalence on the father’s side (n = 20 in the control group, and n = 34 in the studied group) and on the mother’s side (n = 5 in the control group, and n = 32 in the studied group), a statistically significant difference is observed only for hair loss on the mother’s side.

A similar hair loss prevalence on the father’s side in the FPHL group and the control group can be related with the fact that androgenic alopecia is more frequent in men, ranging from 50% among 50-year-old men to nearly 80% over the age of 70 in the Caucasian population [3].

This observation may indicate a greater significance of the family history on the mother’s side in the case of female hair loss. The higher hair loss prevalence in maternal grandmothers may also support this.

Similar results were presented by Salman et al. [7], who noted a significantly higher frequency of a positive history in the mothers and sisters of women with FPHL in comparison with healthy women; however, no such relationship was observed for second-degree relatives.

Moreover, the study did not observe a relationship between the FPHL onset time in women with a positive history on the mother’s side, but it did note such a relationship in men with a positive history on the father’s side.

Contrary to the yet unclear significance of family history in women, a positive family history is undoubtedly a risk factor for androgenic alopecia in men. A study conducted in a male population by Chumlea et al. [12] established the greatest significance of a positive history in the maternal grandfather and the father. Similar results were obtained by Nargis et al. [13], where a positive family history was found in 68% of patients, including 44 (62.8%) with a positive family history in paternal relatives, and only 8.6% with a positive family history in maternal relatives.

This suggests a much greater influence of familial hair loss in male-line relatives on men with AGA.


A positive family history of hair loss concerning more than one person in the studied group confirms the significant role of a positive family history in disease development. A positive family history in over 50% of the female patients may indicate the autosomal dominant inheritance pattern of the trait.

The hair loss prevalence in the studied group was similar on the mother’s and father’s sides, but this might be related to the higher prevalence of androgenic alopecia in men than in women worldwide. The frequent positive family history with respect to the grandparents of women with FPHL highlights the role and the necessity of taking a detailed family history, when assessing the disease development risk at the initial stages of hair loss as well as the necessity of conducting further genetic research.

Strengths: To our best knowledge, this is the first study concerning the genetic origin of female pattern hair loss in women in Poland.

Weaknesses: Lack of ability to verify the type of hair loss/type of alopecia in the family. Lack of knowledge of the entire family structure.

Conflict of interest

The authors declare no conflict of interest.



Paik J, Yoon J, Sim W, et al. , authors. The prevalence and types of androgenetic alopecia in Korean men and women. Br J Dermatol. 2001. 145:p. 95–9


Birch MP, Messenger JF, Messenger AG , authors. Hair density, hair diameter and the prevalence of female pattern hair loss. Br J Dermatol. 2001. 144:p. 297–304


Gan DC, Sinclair RD , authors. Prevalence of male and female hair loss in Maryborough. J Investig Dermatol Symp Proc. 2005. 10:p. 184–9


Norwood OT , author. Incidence of female androgenic alopecia (female pattern alopecia). Dermatol Surg. 2001. 27:p. 53–4


Wang T, Zhou C, Shen Y, et al. , authors. Prevalence of androgenetic alopecia in China: a community-based study in six cities. Br J Dermatol. 2010. 162:p. 843–7


Lin-Hui S, Li-Sheng C, Hsiu-Hsi C , authors. Factors associated with female pattern hair loss and its prevalence in Taiwanese women: a community-based survey. J Am Acad Dermatol. 2013. 69:p. e69–77


Salman K, Altunay I, Kucukunal L, et al. , authors. Frequency, severity and related factors of androgenetic alopecia in dermatology outpatient clinic: hospital-based cross-sectional study in Turkey. An Bras Dermatol. 2017. 92:p. 35–40


Brzeziñska-Wcisło L, Rakowska A, Rudnicka L, et al. , authors. Androgenetic alopecia. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Dermatol Rev. 2018. 105:p. 1–18


Tandon S, Arora P, Gautam RK, et al. , authors. Correlation between clinical features, biochemical parameters, and histopathological findings in women with patterned baldness: a study from North India. J Cutan Aesthet Surg. 2019. 12:p. 42–8


Wei Siah T, Muir-Green L, Shapiro J , authors. Female pattern hair loss: a retrospective study in a tertiary referral center. Int J Trichology. 2016. 8:p. 57–61


Smith M, Wells R , authors. Male-type alopecia, alopecia areata, and normal hair in women: family histories. Arch Dermatol. 1964. 89:p. 95–8


Chumlea WC, Rhodes T, Girman CJ, et al. , authors. Family history and risk of hair loss. Dermatology. 2004. 209:p. 33–9


Nargis T, Vishal B, Pinto M, et al. , authors. Early onset androgenetic alopecia in men and associated risk factors: a hospital based study. Int J Res in Dermatol. 2017. 3:p. 267–71

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