Abstract
3/2011
vol. 10
Original paper
The role of single nucleotide polymorphism Arg399Gln XRCC1 gene in endometrial cancer in Polish postmenopausal women
Przegląd Menopauzalny 2011; 3: 191–196
Online publish date: 2011/07/04
Background: Endometrial cancer is one of the most common malignant neoplasms which appear in the uterine body. X-ray repair cross-complementing 1 (XRCC1) protein can be involved in the repair of DNA lesions, which are known to contribute to endometrial cancer.
Material and methods : The genotype analysis of XRCC1 Arg399Gln gene polymorphisms for 456 endometrial cancer patients and 300 controls of cancer-free subjects in the Polish population was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP).
Results : An association was found between endometrial cancer occurrence and the Gln/Gln genotype of the Arg399Gln polymorphism (odds ratio 2.22; 95% confidence interval 1.51-3.27, p < 0.0001). The Gln/Gln genotype of XRCC1 increased the risk of type I endometrial cancer occurrence (OR = 2.13, 95% CI = 2.02-2.75, p < 0.012).
No statistically significant association was found between gene polymorphisms and endometrial cancer risk factors such as BMI, HRT, uterine bleeding, diabetes and hypertension.
Conclusion : The results support the hypothesis that the Arg399Gln polymorphism of the XRCC1 gene may be associated with the development of sporadic endometrial cancer in Polish women.
Material and methods : The genotype analysis of XRCC1 Arg399Gln gene polymorphisms for 456 endometrial cancer patients and 300 controls of cancer-free subjects in the Polish population was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP).
Results : An association was found between endometrial cancer occurrence and the Gln/Gln genotype of the Arg399Gln polymorphism (odds ratio 2.22; 95% confidence interval 1.51-3.27, p < 0.0001). The Gln/Gln genotype of XRCC1 increased the risk of type I endometrial cancer occurrence (OR = 2.13, 95% CI = 2.02-2.75, p < 0.012).
No statistically significant association was found between gene polymorphisms and endometrial cancer risk factors such as BMI, HRT, uterine bleeding, diabetes and hypertension.
Conclusion : The results support the hypothesis that the Arg399Gln polymorphism of the XRCC1 gene may be associated with the development of sporadic endometrial cancer in Polish women.
Keywords
XRCC1, endometrial cancer, gene polymorphism
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