Journal of Contemporary Brachytherapy

Abstract

1/2020 vol. 12
Review paper

The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review

Valentina Lancellotta 1
,
Francesca De Felice 2
,
Lisa Vicenzi 3
,
Alfredo Antonacci 4
,
Valentina Cerboneschi 5
,
Sara Costantini 3
,
Daniela di Cristino 6
,
Luca Tagliaferri 1
,
Annamaria Cerrotta 7
,
Andrea Vavassori 8
,
Sergio Gribaudo 9
,
Alessandro Colombo 10
,
Francesco Lucà 11
,
Raffaele Barbara 12
,
Monica Mangoni 13
,
Francesco Marampon 2
,
Daniela Musio 2
,
Filippo Bellati 14
,
Francesco Torcia 14
,
Vincenzo Tombolini 2
,
Mattia Falchetto 15
,
Vitaliana De Sanctis 15
  1. Fondazione Policlinico Universitario A. Gemelli IRCCS, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia – Gemelli ART (Advanced Radiation Therapy), Interventional Oncology Center (IOC), Roma, Italy
  2. Department of Radiological, Oncological and Anatomo Pathological Sciences, Azienda Ospedaliero Universitaria Policlinico Umberto I, “Sapienza” University, Rome, Italy
  3. Radiotherapy Unit, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
  4. Radiotherapy Unit, S. Spirito Hospital, Pescara, Italy
  5. Radiotherapy Unit, Department of Oncology, San Luca Hospital, Lucca, Italy
  6. Radiotherapy Unit, Presidio Ospedaliero San Filippo Neri, Roma, Italy
  7. Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  8. Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy
  9. Department of Oncology-Radiotherapy, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy
  10. Division of Radiation Oncology, ASST-Lecco, Ospedale A.Manzoni, Lecco, Italy
  11. Presidente Fondazione Area Radiologica, Roma, Italy
  12. UOC Radioterapia Oncologica, Azienda Ospedaliera “Brotzu”, Cagliari, Italy
  13. Radiotherapy Unit, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Mario Serio, University of Florence, Firenze, Italy
  14. Department of Medicine and Surgery and Translational Medicine, Gynecology Unit, Sant’ Andrea University Hospital, “Sapienza” University, Rome, Italy
  15. Department of Medicine and Surgery and Translational Medicine, Radiotherapy Oncology, Sant’ Andrea Hospital, “Sapienza” University, Rome, Italy
J Contemp Brachytherapy 2020; 12, 1: 61–66
DOI: https://doi.org/10.5114/jcb.2020.92698
Online publish date: 2020/02/28
View full text

Purpose

Serous adenocarcinoma (uterine serous carcinoma – USC) is a rare and aggressive histologic subtype of endometrial cancer, with a high-rate of recurrence and poor prognosis. The adjuvant treatment for stage I patients is unclear. The purpose of this study was to evaluate the outcomes of stage I USC treated exclusively with chemotherapy plus vaginal brachytherapy (VBT).

Material and methods

A systematic research using PubMed, Scopus, and Cochrane library was conducted to identify full articles evaluating the efficacy of VBT in patients with stage I USC. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials, and in PROSPERO for searching ongoing or recently completed systematic reviews.

Results

All studies were retrospective and 364 of evaluated patients were found. The average local control was 97.5% (range, 91-100%), the disease free-survival was 88% (range, 82-94%), the overall survival was 93% (range, 72-100%), the specific cancer survival was 89.4% (range, 84.8-94%), and the G3-G4 toxicity was 0-8%.

Conclusions

These data support the concept that in adequately selected patients, VBT alone may be a suitable radiotherapy technique in women with stage I USC who underwent surgical staging and received adjuvant chemotherapy.

Keywords

serous adenocarcinoma, endometrial cancer, brachytherapy, outcomes

Share
without publication fees
Indexed in
pubmed
Integrated with
integrated with publons
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications