Tramadol-induced anaphylaxis: a rare confirmed case

Anna Ochmann; Joanna Glück; Radosław Gawlik

doi:10.5114/pja.2025.153700

eISSN: 2391-6052
ISSN: 2353-3854

Alergologia Polska - Polish Journal of Allergology

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3/2025
vol. 12

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Tramadol-induced anaphylaxis: a rare confirmed case

Anna Ochmann

¹

,

Joanna Glück

¹

,

Radosław Gawlik

¹

Department of Internal Medicine, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland

Alergologia Polska – Polish Journal of Allergology 2025; 12, 3: 218–221

DOI: https://doi.org/10.5114/pja.2025.153700

Data publikacji online: 2025/08/20

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Metryki PlumX:

Tramadol is an opioid agonist that can be utilized for managing moderate chronic pain in adults. It is recognized for its safety and high tolerance. In comparison to other morphine-like drugs, it results in fewer adverse effects. Allergic reactions have been documented in several cases, though the occurrence was below 0.1%. The existing literature includes only a limited number of publications regarding documented hypersensitivity reactions following tramadol usage. We present the case of a 51-year-old woman with scoliosis and multilevel discopathy, who experienced two instances of anaphylactic shock: the first occurred following the use of an unidentified painkiller and the second happened after she took tramadol drops. In June 2024, she was admitted to our Allergology Unit with a suspected diagnosis of hypersensitivity to analgesic drugs. Given very low likelihood of anaphylaxis to tramadol, we chose to conduct an allergological evaluation that includes tramadol and other synthetic opioids.

Tramadol-induced anaphylaxis: a rare confirmed case

Anna Ochmann 1 , Joanna Glück 1 , Radosław Gawlik 1

Anna Ochmann

¹

,

Joanna Glück

¹

,

Radosław Gawlik

¹