eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2004
vol. 29
 
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abstract:

Two murine homologues of human MCP-1 chemokine are differently expressed during intracellular infection with Listeria strains

Bożena Dziadek
,
Jarosław Dziadek
,
Tomasz Popławski
,
Teresa Gościcka

Centr Eur J Immunol 2004; 29 (1): 23-28
Online publish date: 2004/12/22
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The murine cells express two homologues of human MCP-1 βb-chemokine, which plays a crucial protective role in the early phase of immunological response against intracellular pathogens. We have found that the expression of mRNA for murine MCP-1/JE and MCP-5 CC-chemokines is upregulated in peritoneal exudate cells during Listeria infection. The MCP-5 mRNA expression was observed exclusively in the early stage of infection with both pathogenic and nonpathogenic Listeria strains. The upregulation of MCP-1/JE mRNA production depended on strain pathogenicity and increased gradually during four hours postinfection.
keywords:

cytokines, chemokines, monocyte chemotactic protein-1/JE (MCP-1/JE), monocyte chemotactic protein-5 (MCP-5), listeriosis

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