eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2017
vol. 68
 
Share:
Share:
more
 
 
abstract:
Original paper

Ultrastructural liver changes in the experimental thyrotoxicosis

Nadiya Vasylivna Pasyechko, Iryna Ihorivna Kuleshko, Veronika Mykolaiivna Kulchinska, Liudmyla Valeriivna Naumova, Iryna Volodymyrivna Smachylo, Anzhela Olehivna Bob, Liudmyla Volodymyrivna Radetska, Mykhailo Yevhenovych Havryliuk, Olha Mykolaiivna Sopel, Liudmyla Petrivna Mazur

Pol J Pathol 2017; 68 (2): 144-147
Online publish date: 2017/09/01
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Aim of the study is to evaluate ultrastructural changes of rat liver in experimental thyrotoxicosis.

For the study, 36 male rats have been utilized, weighing approximately 150-190 g, which were divided into three groups: the first, control group (12 animals) was composed of healthy rats that received intragastric sodium chloride 0.9% solution, the second group (12 animals) – animals with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 2 weeks, and the third group (12 animals) – rats with experimental thyrotoxicosis, which received intragastric solution of L-thyroxine at the rate of 200 μg/kg for 4 weeks. For electron-microscopic studies small pieces of liver tissue were taken at the end of the 2nd and 4th weeks of the experiment. The material was studied and documented in electron micrographs by using a TEM-125K electron microscope.

In experiment in white male rats the electron-microscopic state of the liver in thyrotoxicosis has been studied. It has been established that thyrotoxicosis is accompanied by the significant changes of the hepatocytes ultrastructure, blood and bile capillaries. Experimental thyrotoxicosis causes significant damage of the liver plasma membranes and intracellular structural components of hepatocytes and endothelial cells.

In experimental thyrotoxicosis, on the background of microcirculatory disorders, significant damage of plasmatic and intracellular organoid membranes of hepatocytes in the liver develops, which has an adverse effect on the functionality of the organ. The found ultrastructural changes are aggravated depending on the duration of thyrotoxicosis.
keywords:

thyrotoxicosis, liver, ultrastructural changes, rat

references:
Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM 2002; 95: 559-569.
Leonard JL, Koehrle J. Intracellular pathways of iodothyronine metabolism. In: Braverman LE, Utiger R (eds). The Thyroid. Lippincott-Raven Publishers, Philadelphia 1996; 125-161.
Larsen PR, Berry MJ. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr 1995; 15: 323-352.
Visser TJ. Pathways of thyroid hormone metabolism. Acta Med Austriaca 1996; 23: 10-16.
Sola J, Pardo‐Mindan FJ, Zozaya J, et al. Liver changes in patients with hyperthyroidism. Liver 1991; 11: 193-197.
Daher R, Yazbeck T, Jaoude JB, Abboud B. Consequences of dysthyroidism on the digestive tract and viscera. World J Gastroenterol 2009; 15: 2834-2838.
Bayraktar M, Van Thiel DH. Abnormalities in measures of liver function and injury in thyroid disorders. Hepatogastroenterology 1997; 44: 1614-1618.
Sellin JH, Vassilopoulou-Sellin R. The gastrointestinal tract and liver in thyrotoxicosis. In: Braverman LE, Utiger RD (eds.). The Thyroid, 9th edition. Lippincott Williams & Wilkins, New York 2005; 622-626.
Sarkisov DS, Petrova YuL. Mikroskopicheskaya tehnika. Me­ditsina, Moskva 1996: 1-544.
Chedid A, Mendenhall CL, Tosch T, et al. Significance of megamitochondria in alcoholic liver disease. Gastroenterology 1986; 90: 1858-1864.
Ashrafov RA, Lychkova AÉ. Dynamics of ultrastructural organization of liver cells in experimental peritonitis. Eksp Klin Gastroenterol 2013; (12): 75-78.
Tekln S, Türker H, Güven T, Yel M. The effects of ultraviolet C radiation on the ultrastructure of the liver cells of mole rats. Ultrastruct Pathol 2016; 40: 51-56.
Mahmoud YI, Hegazy HG. Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver. Biotech Histochem 2016; 91: 86-95.
Huang MJ, Liaw YF. Clinical associations between thyroid and liver diseases. J Gastroenterol Hepatol 1995; 10: 344-350.
Upadhyay G, Singh R, Kumar A, et al. Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver. Hepatology 2004; 39: 1120-1130.
FEATURED PRODUCTS
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe