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vol. 49
Original paper

Measurement of pain relief resulting from the administration of Perna canaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of knee and/or hip joints

Jacek Szechiński, Marek Zawadzki

Reumatologia 2011; 49, 4: 244-252
Online publish date: 2011/08/30
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Aim : To compare with baseline, pain relief, changes in the indicators of quality of life and safety for osteoarthritis patients taking a patented CO2 stabilised oil from the NZ Greenshell Mussel Perna canaliculus (PCSO-524™) as compared with patients taking fish oil (containing an industry standard EPA – 18% and DHA – 12% blend).

Material and methods: 50 patients older than 50 years from the Rheumatology Clinic at the Wroclaw Medical University Hospital were administered randomly either Lyprinol® capsules that contained PCSO-524™ or fish oil capsules in a double-blind study. All subjects had a diagnosed history of osteoarthritis of the knee and/or the hip. The patients characteristics are presented in Tables I and II. At baseline and then after four, eight and 12 weeks of treatment, information was collected using first, the visual analogue scale (VAS) for pain; second, the health assessment questionnaire (HAQ); and third, the patient’s own overall assessment of the progression of osteoarthritis and their health condition. For patient safety control, before enrolment in the study and at the end of the study, patients had a blood cell count, ESR, ALAT and urine analysis.

Results : Patients treated with PCSO-524™ showed a statistically significant improvement of both their pain symptoms related to osteoarthritis and improved quality of their daily lives (Tables III-V, Fig. 1, 2). No side effects were observed in patients who took PCSO-524™ (p < 0.05). Patients treated with fish oil showed significantly less improvement and a greater level of physical discomfort caused by the fish oil during the study (Table VI).

Conclusions : Reduction of pain was statistically evident at four weeks among the subjects who took capsules that contained PCSO-524™. Practitioners can expect quicker long-term results with less risk of side effects for their osteoarthritis patients when they recommend products that contain PCSO-524™, compared with fish oil.

osteoarthritis, oil from Greenshell Mussel, fish oil

Mickleborough TD, Lindley MR, Ionescu AA, Fly AD. Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest 2006; 129: 39-49.  
Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980; 224: 955-960. 
Gibson SL, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus, a randomised trial. Complementary Ther Med 1998; 6: 122-126. 
Gibson SL. The effect of a lipid extract of the New Zealand green-lipped mussle on three cases of arthritis. J Altern Complement Med 2000; 6: 351-354. 
Lau CS, Chiu PKY, Chu EMY, et al. Treatment of knee osteoarthritis with Lyprinol®, lipid extract of the green-lipped mussel – a double-blind placebo-controlled study. Progress Nutr 2004; 6: 17-31. 
Cho SH, Jung YB, Seong SC, et al. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna canaliculus) in patients with osteoarthritis of the hip and knee: a multi-centre two-month clinical trial. Eur Ann Allergy Clin Immunol 2003; 35: 212-216. 
McPhee S, Hodges LD, Wright PF, et al. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol 2007; 146: 346-356. 
Singh M, Hodges LD, Wright PF, et al. The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats. Comp Biochem Physiol B Biochem Mol Biol 2008; 149: 251-258. 
Treschow AP, Hodges LD, Wright PF, et al. Novel anti-inflammatory w-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol 2007; 147: 645-656. 
Sinclair AJ, Murphy KJ, Li D. Marine lipids: overview new insights and lipid composition of Lyprinol®”. Allerg Immunol (Paris) 2000; 32: 261-271.
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