Review paper Natural TH2 (nTH2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal; Alicja Trzeciak-Ryczek; Beata Tokarz-Deptuła; Wiesław Deptuła

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

2/2011
vol. 36

Send email

Copy url:

abstract:

Review paper
Natural T_H2 (nT_H2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal

,

Alicja Trzeciak-Ryczek

,

Beata Tokarz-Deptuła

,

Wiesław Deptuła

(Centr Eur J Immunol 2011; 36 (2): 113-116)

Online publish date: 2011/06/20

View full text Get citation

This paper presents new elements of innate immunity, such as recently described natural T_H2 cells (nT_H2 or NHC), interleukin 36 (IL-36) and IL-37. nT_H2 cells are located in structures defined as fat-associated lymphoid clusters (FALC), and their role is principally associated with the production of cytokines that are characteristic for T_H2 lymphocytes participating in the course of allergic processes and in host defence during invasions of various parasites. The expression of IL-36 was mainly recorded in the thymus, testis and uterus cells. This interleukin indicates suppressive effect on innate immunity, principally by inhibition of pro-inflammatory cytokine production, as well as by creation of an active complex with signalling protein – Smad3 and cooperation with TGF-β. In turn, IL-37 is synthesized in the same places as IL-36, and additionally in macrophages and epithelial cells. It is also considered as an inhibitor of innate immunity.

keywords:

Review paperNatural TH2 (nTH2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal , Alicja Trzeciak-Ryczek , Beata Tokarz-Deptuła , Wiesław Deptuła

innate immunity, nTH2 cells, IL-36, IL-37

Review paper
Natural T_H2 (nT_H2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal

,

Alicja Trzeciak-Ryczek

,

Beata Tokarz-Deptuła

,

Wiesław Deptuła

innate immunity, nT_H2 cells, IL-36, IL-37