eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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abstract:
Review paper

A novel tool for visualization and detection of pancreatic neuroendocrine tumours. A ‘fluorescent’ world is calling for exploration?

Maria Sotiropoulou
1
,
Francesk Mulita
2
,
Georgios-Ioannis Verras
2
,
Dimitrios Schizas
1
,
Alexandros Papalampros
1
,
Levan Tchabashvili
2
,
Charalampos Kaplanis
2
,
Elias Liolis
3
,
Ioannis Perdikaris
2
,
Ioannis Maroulis
2
,
Michail Vailas
2

1.
Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece
2.
Department of Surgery, General University Hospital of Patras, Greece
3.
Department of Internal Medicine, Division of Oncology, General University Hospital of Patras, Greece
Menopause Rev 2021; 20(4)
Online publish date: 2021/11/16
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Introduction
Pancreatic neuroendocrine tumours (pNETs) are rare tumours with a propensity to metastasize. Physicians frequently face a huge clinical challenge during the localization of these lesions. The aim of this study is to investigate whether fluorescence-guided localization techniques with indocyanine green (ICG) can be utilized as a detection tool in pNETs, along with any other clinical implications of this technique.

Material and methods
A thorough literature search in PubMed and Google Scholar, under the terms ‘ICG OR Indocyanine OR Fluorescence AND Neuroendocrine’ until 31 June 2021, regarding the utilization of indocyanine-fluorescence in localization of pancreatic neuroendocrine, was conducted by the authors, and the associated results are presented.

Results
Indocyanine fluorescence imaging may facilitate the efforts of surgeons to identify occult pancreatic neuroendocrine lesions, assisting them in the identification of resection margins and delineation of the surgical anatomy when it is difficult to clarify.

Conclusions
Indocyanine-fluorescence imaging might play a pivotal role in pancreatic surgery in terms of localization for neuroendocrine tumours. However, further large-scale clinical studies are needed to assess the absolute indications and optimal use of this technique.

keywords:

cancer, fluorescence, ICG, indocyanine, neuroendocrine, pancreas

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