Acral peeling skin syndrome

Introduction:
Acral peeling skin syndrome is a rare syndrome inherited in an autosomal recessive manner. A mutation in the gene encoding transglutaminase 5 is responsible for the onset of the disease. Initial symptoms manifest in early childhood. Clinically, it is characterised by exfoliation of the epidermis of the hands and feet. Skin lesions are exacerbated during periods of increased humidity and ambient temperature, increased sweating and as a result of trauma.

Objective:
To present the case of a 13-year-old boy diagnosed with acral peeling skin syndrome.

Case report:
A 13-year-old patient presented to the dermatology clinic with flaccid blisters and exfoliation on the feet. The skin lesions were exacerbated during periods of increased sweating. A p.Gly113Cys mutation was detected in both alleles of the TGM5 gene.

Conclusions:
We present this case because of the rare occurrence of acral peeling skin syndrome in the population. The disease can be a challenge to diagnose due to its significant similarity to dyshidrotic eczema, with which it is often confused.