eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
vol. 20
Review paper

Acupuncture: could it become everyday practice in oncology?

Aneta Kilian-Kita
Mirosława Puskulluoglu
Kamil Konopka
Krzysztof Krzemieniecki

Contemp Oncol (Pozn) 2016; 20 (2): 119-123
Online publish date: 2016/06/14
Article file
- Acupuncuture.pdf  [0.10 MB]
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero


Complementary and alternative medical treatment (CAM) has gained significant interest in recent years [1]. Although the list of CAM has changed over the years, the Office of Alternative Medicine (established at the National Institutes of Health [NIH] in the USA) nowadays recognizes five major categories [2]. Acupuncture, belonging to the Manipulative Therapies category, due to its low cost, safety (considering all possible contraindications) and the minimal number of side effects is gaining popularity among patients [3]. Acupuncture has repeatedly been reported to be useful in oncological practice in alleviating side effects of anti-tumor treatment. Numerous clinical trials of acupuncture indicate its potential role in fighting the following ailments: nausea and chemotherapy-induced vomiting, pain, xerostomia, vasomotor symptoms, neutropenia, fatigue, anxiety, insomnia, lymphoedema after mastectomy, and peripheral neuropathy [4–16]. A sudden increase in the number of studies on acupuncture in oncology was first noted in 1997, when at the NIH conference a consensus was reached on the use of acupuncture, which was then acknowledged as a useful medical procedure [17]. This article reviews the literature concerning the referred studies.

What is acupuncture?

Acupuncture is a method of treatment that has its origins in Traditional Chinese Medicine and is based on over 4,000 years of empirical evidence. The technique involves the insertion of thin needles into specific locations (energy points) on the patient’s body along energy pathways or meridians. According to Chinese philosophy, the hypothetical substance Qi (vital energy) flows in the human body along the meridians, and blockage of Qi leads to a particular ailment [18]. There are 12 main and 8 extra meridians. All the main meridians consist of internal channels connected with the 12 body organs and the external channels spreading symmetrically on the skin surface. The literature describes around 360 energy points located on the external parts of the meridians. Acupuncture is considered to cure diseases by stimulating particular acupoints and removing blockage of Qi [19]. Figures 1–3 present acupuncture meridian pathways.
Although acupuncture has been studied extensively in both animal and human models, little is known about its mechanisms that could explain acupuncture’s therapeutic qualities. Table 1 shows suggested mechanisms of acupuncture. This treatment method has been the focus of increased interest, which has resulted in a growing number of studies.

Acupuncture as supportive treatment

Chemotherapy agents are considered to be medications with the most severe side effects, which in many cases may force the patient to abandon therapy. Because of that, proper alleviation of side effects is most crucial. Acupuncture should not be seen as a replacement for modern medicines, but rather an adjunct with a low level of procedure-related complications that may enhance efficacy and in some cases allow the dosage of other drugs to be reduced. Acupuncture as part of supportive treatment in oncology has been tested for numerous indications. The strongest evidence from a randomized controlled trial (RCT) with low risk of bias supports the use of acupuncture for control of nausea and vomiting related to chemotherapy [25]. This indication seems to be very important, as the high emetogenicity of many cytostatic agents is hard to control even with three-drug therapy [26]. Despite many RCTs on treatment of other chemotherapy-induced side effects, the level of evidence is not yet satisfactory, but considering its relative safety, acupuncture may be useful in everyday practice. Descriptions of these clinical trials on the effectiveness of acupuncture in minimizing cancer treatment-related side effects are summarized in Table 2.

Level of evidence issue

A recently published systemic review stated that other indications, such as pain, xerostomia, vasomotor symptoms, fatigue, mood disorders, and insomnia, were not evaluated in RCTs with an appropriate level of evidence [44]. One of the major problems with the reviewed studies is their poor methodological quality, mostly difficulty with blinding and a low number of subjects. Also the optimal design of such studies (acupuncture vs placebo, acupuncture vs sham acupuncture) has not been established yet [45]. In spite of satisfactory results in most of these studies, further research on a larger group of patients is necessary.


In an oncological setting, acupuncture is still being constantly reviewed. Nevertheless, the present available evidence suggests that acupuncture may become a safe, low-cost and efficient form of complementary therapy in modern oncology. The potential role of acupuncture has been found in alleviation of various symptoms, but the data from the majority of clinical studies on acupuncture are heterogeneous. The incomplete description of procedural methodology and insufficient patient groups limit their value. Thus, further research on a larger scale on the potential use of acupuncture in contemporary oncology is required. It should be emphasized that alternative medicine may become the source of a number of interesting concepts worth examining and testing in research and clinical settings.


The authors would like to thank Ms Joanna Gołąb for editing the article.

The authors declare no conflict of interest.


1. Molassiotis A, Fernadez-Ortega P, Pud D, et al. Use of complementary and alternative medicine in cancer patients: a European survey. Ann. Oncol 2005; 16: 655-63.
2. Hök J, Tishelman C, Ploner A, et al. Mapping patterns of complementary and alternative medicine use in cancer: an explorative cross-sectional study of individuals with reported positive “exceptional” experiences. BMC Complement Altern Med 2008; 8: 48.
3. White A. A cumulative review of the range and incidence of significant adverse events associated with acupuncture. Acupunct Med 2004; 22: 122-33.
4. Streitberger K, Ezzo J, Schneider A. Acupuncture for nausea and vomiting: an update of clinical and experimental studies. Auton Neurosci 2006; 129: 107-17.
5. Yang Y, Zhang Y, Jing N, et al. Electroacupuncture at Zusanli (ST 36) for treatment of nausea and vomiting caused by the chemotherapy of the malignant tumor: a multicentral randomized controlled trial. Zhongguo Zhen Jiu 2009; 29: 955-8.
6. Gottschling S, Reindl TK, Meyer S, et al. Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology – a randomized multicenter crossover pilot trial. Klin Padiatr 2008; 220: 365-70.
7. Dang W, Yang J. Clinical study on acupuncture treatment of stomach carcinoma pain. J Tradit Chin Med 1998; 18: 31-8.
8. Alimi D, Rubino C, Pichard-Léandri E, et al. Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled trial. J Clin Oncol 2003; 21: 4120-6.
9. Braga FP, Lemos Junior CA, Alves FA, Migliari DA. Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer. Braz Oral Res 2011; 25: 180-5.
10. Liljegren A, Gunnarsson P, Landgren B-M, et al. Reducing vasomotor symptoms with acupuncture in breast cancer patients treated with adjuvant tamoxifen: a randomized controlled trial. Breast Cancer Res. Treat. 2012; 135: 791-8.
11. Lu W, Matulonis UA, Doherty-Gilman A, et al. Acupuncture for chemotherapy-induced neutropenia in patients with gynecologic malignancies: a pilot randomized, sham-controlled clinical trial. J Altern Complement Med 2009; 15: 745-53.
12. Molassiotis A, Sylt P, Diggins H. The management of cancer-related fatigue after chemotherapy with acupuncture and acupressure: a randomised controlled trial. Complement Ther Med 2007; 15: 228-37.
13. Eich H, Agelink MW, Lehmann E, et al. Acupuncture in patients with minor depressive episodes and generalized anxiety. Results of an experimental study. Fortschr Neurol Psychiatr 2000; 68: 137-44.
14. Frisk J, Källström A-C, Wall N, et al. Acupuncture improves health-related quality-of-life (HRQoL) and sleep in women with breast cancer and hot flushes. Support Care Cancer 2012; 20: 715-24.
15. Cassileth BR, Van Zee KJ, Chan Y, et al. A safety and efficacy pilot study of acupuncture for the treatment of chronic lymphoedema. Acupunct Med 2011; 29: 170-2.
16. Donald GK, Tobin I, Stringer J. Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupunct Med 2011; 29: 230-3.
17. NIH. Consensus Conference. Acupuncture. JAMA 1998; 280: 1518-24.
18. Zhao XL, Han JX. The connotation of the Quantum Traditional Chinese Medicine and the exploration of its experimental technology system for diagnosis. Drug Discov Ther 2013; 7: 225-32.
19. Perlow BW. Acupuncture: its theory and use in general practice. Proc R Soc Med 1973; 66: 426-8.
20. Chae Y, Hong M-S, Kim G-H, et al. Protein array analysis of cytokine levels on the action of acupuncture in carrageenan-induced inflammation. Neurol Res 2007; 29: S55-8.
21. Su T-F, Zhao Y-Q, Zhang L-H, et al. Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB2 receptors. Eur J Pain 2012; 16: 624-35.
22. Anderson B, Nielsen A, McKee D, et al. Acupuncture and heart rate variability: a systems level approach to understanding mechanism. Explore (NY) 2012; 8: 99-106.
23. Moldenhauer S, Burgauner M, Hellweg R, et al. Mobilization of CD133(+)CD34(-) cells in healthy individuals following whole-body acupuncture for spinal cord injuries. J Neurosci Res 2010; 88: 1645-50.
24. Yang Z, Chen P, Yu H, et al. Research advances in treatment of cerebral ischemic injury by acupuncture of conception and governor vessels to promote nerve regeneration. Zhong Xi Yi Jie He Xue Bao 2012; 10: 19-24.
25. Shen J, Wenger N, Glaspy J, et al. Electroacupuncture for control of myeloablative chemotherapy-induced emesis: A randomized controlled trial. JAMA 2000; 284: 2755-61.
26. Gralla RJ, de Wit R, Herrstedt J, et al. Antiemetic efficacy of the neurokinin-1 antagonist, aprepitant, plus a 5HT3 antagonist and a corticosteroid in patients receiving anthracyclines or cyclophosphamide in addition to high-dose cisplatin: analysis of combined data from two Phase III randomized clinical trials. Cancer 2005; 104: 864-8.
27. Han J-S. Acupuncture and endorphins. Neurosci Lett 2004; 361: 258-61.
28. Han JS, Xie GX, Zhou ZF, et al. Acupuncture mechanisms in rabbits studied with microinjection of antibodies against beta-endorphin, enkephalin and substance P. Neuropharmacology 1984; 23: 1-5.
29. Wu GC, Zhu J, Cao X. Involvement of opioid peptides of the preoptic area during electroacupuncture analgesia. Acupunct Electrother Res 1995; 20: 1-6.
30. Hsieh JC, Tu CH, Chen FP, et al. Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study. Neurosci Lett 2001; 307: 105-8.
31. Choi TY, Lee MS, Kim TH, et al. Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Support Care Cancer 2012; 20: 1147-58.
32. Zhao X, Wang H, Tian K, et al. Review on mechanisms of acupuncture-moxibustion against leukopenia due to chemotherapy induced myeloid inhibition. Acupuncture Research 2003; 1: 70-3.
33. Zhao X, Huang X, Wang H, et al. Study on the Mechanism of Acupuncture in Fighting Chemotherapeutic Marrow Depression and Enhancing WBC. Shanghai Journal of Acupuncture and Moxibustion 2003; 1: 29-33.
34. Lu W, Hu D, Dean-Clower E, et al. Acupuncture for chemotherapy-induced leukopenia: exploratory meta-analysis of randomized controlled trials. J Soc Integr Oncol 2007; 5: 1-10.
35. Crew KD, Capodice JL, Greenlee H, et al. Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol 2010; 28: 1154-60.
36. Deng G, Hou BL, Holodny AI, Cassileth BR. Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study. BMC Complement Altern Med 2008; 8: 37.
37. Dawidson I, Angmar-Mânsson B, Blom M, et al. Sensory stimulation (acupuncture) increases the release of calcitonin gene-related peptide in the saliva of xerostomia sufferers. Neuropeptides 1999; 33: 244-50.
38. Spetz Holm A-CE, Frisk J, Hammar ML. Acupuncture as treatment of hot flashes and the possible role of calcitonin gene-related Peptide. Evid Based Complement Alternat Med 2012; 2012: 579321.
39. Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast 2013; 22: 320-3.
40. Park HJ, Chae Y, Jang J, et al. The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats. Neurosci Lett 2005; 377: 179-84.
41. Chae Y, Yeom M, Han JH, et al. Effect of acupuncture on anxiety-like behavior during nicotine withdrawal and relevant mechanisms. Neurosci Lett 2008; 430: 98-102.
42. Lu W, Posner MR, Wayne P, et al. Acupuncture for dysphagia after chemoradiation therapy in head and neck cancer: a case series report. Integr Cancer Ther 2010; 9: 284-90.
43. Ge AX, Ryan ME, Giaccone G, et al. Acupuncture treatment for persistent hiccups in patients with cancer. J Altern Complement Med 2010; 16: 811-6.
44. Garcia MK, McQuade J, Haddad R, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol 2013; 31: 952-60.
45. White AR, Filshie J, Cummings TM; International Acupuncture Research Forum. Clinical trials of acupuncture: consensus recommendations for optimal treatment, sham controls and blinding. Complement Ther Med 2001; 9: 237-45.

Address for correspondence

Mirosława Puskulluoglu

Department of Clinical Oncology
University Hospital in Krakow
Śniadeckich 10
31-501 Krakow, Poland
e-mail: mircoll@wp.pl

Submitted: 16.03.2014
Accepted: 16.07.2014
Copyright: © 2016 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2020 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe