Angiogenesis in rheumatoid arthritis

Anna Kotulska; Eugeniusz J. Kucharz

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

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1/2011
vol. 49

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abstract:

Editorial

Angiogenesis in rheumatoid arthritis

Anna Kotulska

,

Eugeniusz J. Kucharz

Reumatologia 2011; 49, 1: 1–9

Online publish date: 2011/03/16

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Angiogenesis is the process of formation of new capillary blood vessels that are generated from pre-existing capillaries. Angiogenesis occurs in postnatal life and is regulated by a complex of proangiogenic and antiangiogenic factors (table I). Upregulated angiogenesis accompanies a few pathological conditions. It is indispensable for growth of malignant tumors. Non-neoplastic diseases are also associated with enhanced angiogenesis, including rheumatoid arthritis. Formation of new vessels was revealed in the inflammed synovial membrane, a key phenomenon of rheumatoid arthritis. Disregulation of pro- and anti-angiogenic factors was shown in rheumatoid patients. Drugs known to inhibit synovitis were found to effect (directly or indirectly) intensity of angiogenesis. It is possible that control of angiogenesis may be one of therapeutical mechanisms of pharmacological management of patients with rheumatoid arthritis.

keywords:

angiogenesis, rheumatoid arthritis, synovitis

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Angiogenesis in rheumatoid arthritis

Anna Kotulska , Eugeniusz J. Kucharz

angiogenesis, rheumatoid arthritis, synovitis

Anna Kotulska

,

Eugeniusz J. Kucharz