Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
Current Issue Manuscripts accepted About the journal Editorial board Abstracting and indexing Archive Ethical standards and procedures Contact Instructions for authors Journal's Reviewers Special Information
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2021
vol. 38
 
Share:
Share:

Association between peroxisome proliferator-activated receptor-alpha, -delta and -gamma gene (PPARA, PPARD, PPARG) polymorphisms and overweight parameters in physically active men

Ewelina Maculewicz
1
,
Andrzej Mastalerz
1
,
Agnieszka Maciejewska-Skrendo
2
,
Paweł Cięszczyk
2
,
Anna Cywińska
3
,
Anna Borecka
4
,
Aleksandra Garbacz
5
,
Ewa Szarska
4
,
Łukasz Dziuda
6
,
Katarzyna Lorenz
1
,
Roman Łakomy
4
,
Tomasz Lepionka
4
,
Anna Anyżewska
4
,
Agnieszka Białek
7
,
Jerzy Bertrandt
8

1.
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
2.
Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
3.
Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
4.
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
5.
Warsaw University of Life Sciences - SGGW, 02-787 Warsaw, Poland
6.
Military Institute of Aviation Medicine, Warszawa, 01-755, Poland
7.
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Magdalenka, Poland
8.
Faculty of Health Sciences. Pope John Paul II State School of Higher Education in Biała Podlaska, 21-500 Biała Podlaska, Poland
Biol Sport. 2021;38(4):767–776
Online publish date: 2021/12/28
Article file
- 32_PPARD_Article.pdf  [0.36 MB]
Get citation
 
PlumX metrics:
 
1. Agha M, Agha R. The rising prevalence of obesity: part A: impact on public health. Int J Surg Oncol. 2017;2:e17, doi:10.1097/ij9.0000000000000017.
2. Stienstra R, Duval C, Műller M, Kersten S. PPARs, Obesity, and Inflammation. PPAR Res. 2007; doi:10.1155/2007/95974.
3. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology. 1996; 137:354–366.
4. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzales FJ, Grimaldi PA, Kadowaki T, Lazar MA, O’Rahilly S, Palmer CAN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International union of pharmacology. LXI. Peroxisome proliferatoractivated receptors. Pharmacol Rev. 2006; 58:726–741.
5. Nuclear Receptors Nomenclature Committee. A unified nomenclature system for the nuclear receptor superfamily. Cell. 1999; 97:1–3.
6. Maciejewska-Karwowska A. Polymorphic variants of the PPAR (Peroxisome Proliferator-Activated Receptor) genes: relevance for athletic performance. Trends Sport Sci 2013; 1(20):5–15.
7. Luo W, Guo Z, Wu M, Hao Ch, Hu X, Zhou Z, Zhou Z, Yao X, Zhang L, Jingchao L. Association of Peroxisome Proliferator-Activated Receptor α/δ/γ With Obesity, and Gene–Gene Interaction, in the Chinese Han Population. J Epidemiol. 2013; doi:10.2188/jea.JE20120110
8. Mandard S, Müller, Kersten S. Peroxisome proliferator-activated receptor α target genes. Cell Mol Life Sci. 2004;61(4):393–416.
9. Kersten S. Integrated physiology and systems biology of PPARα. Mol Metab. 2014;3:354-371.
10. Grarup N, Albrechtsen A, Ek J, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O. Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middleaged white people. Diabetologia. 2007; 50(6):1201–1208.
11. Seedorf U, Aberle J. Emerging roles of PPARdelta in metabolism. Biochim Biophys Acta. 2007; 1771(9):1125–1131.
12. Lehrke M, Lazar M. The Many Faces of PPARγ. Cell. 2005; 123:993–999.
13. WHO. Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation; WHO Technical Report Series 894; WHO: Geneva, Switzerland. 2000; pp. 1–253.
14. Kelly T, Wilson W, Heymsfield B. Dual Energy X-Ray Absorptiometry Body Composition Reference Values from NHANES. PLOS ONE. 2009; 4, e7038
15. R Foundation for Statistics Computing, https://cran.r-project.org, version 2.0-1
16. Bastard J, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Net. 2006; 17(1):4–12.
17. Balistreri C, Caruso C, Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediat Inflamm. 2010; 19, doi:10.1155/2010/802078.
18. Goni L, García-Granero M, Milagro FI, Cuervo M, Martínez JA. Phenotype and genotype predictors of BMI variability among European adults. Nutr Diabetes. 2018;8:27, DOI 10.1038/s41387-018- 0041-1
19. Bosse Y, Despre´s JP, Bouchard C, Pe´russe L, Vohl MC. The Peroxisome Proliferator-Activated Receptor alpha L162V Mutation Is Associated with Reduced Adiposity. Obes Res. 2003; 11:809–816.
20. Silbernagel G, Stefan N, Hoffmann MM, Machicao-Arano F, Machann J, Schick F, Winkelmann B, Boehm B, Häring H, Fritsche A, März W. The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition. Exp Clin Endocrinol Diabetes. 2009; 117:113–118.
21. Evans D, Aberle J, Wendt D, Wolf A, Beisiegel U, Mann W. A polymorphism, L162V, in the peroxisome proliferator-activated receptor α (PPARα) gene is associated with lower body mass index in patients with non-insulin-dependent diabetes mellitus. J Mol Med. 2001; 79:198–204.
22. Andrulionyte L, Kuulasmaa T, Chiasson JL, Laakso M. Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor-Alpha Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes The STOP-NIDDM Trial. Diabetes. 2007; 56:1181–1186.
23. Tai E, Demissie S, Cupples L, Corella D, Wilson P, Schaefer E, Ordovas J. Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels. The Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 2002; 22:805–810.
24. Aberle J, Hopfer I, Beil FU, Seedorf U. Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. Int J Obes. 2006; 30:1709–1713.
25. Vänttinen M, Nuutila P, Kuulasmaa T, Pihlajamäki J, Hällsten K, Virtanen K, Lautamäki R, Peltoniemi P, Takala T, Viljanen A, Knuuti J, Laakso M. Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake. Diabetes. 2005;54:3587–3591.
26. Thamer C, Machann J, Stefan N, Schafer S, Machicao F, Staiger H, Laakso M, Böttcher M, Claussen C, Schick F, Fritsche A, Haring HU. Variations in PPARD Determine the Change in Body Composition during Lifestyle Intervention: A Whole-Body Magnetic Resonance Study. J Clin Endocrinol Metab. 2008; 93(4):1497–1500.
27. Villegas R, Williams S, Gao Y, Cai Q, Li H, Elasy T, Cai H, Edwards T, Xiang YB, Zheng W, Long J, Shu XO. Peroxisome proliferator-activated receptor (PPAR) delta genetic variation and type 2 diabetes in middle age Chinese women. Ann Hum Genet. 2011; 75(5):621–629.
28. Shin HD, Park BL, Kim LH, Jung HS, Cho YM, Moon MK, Park YJ, Lee HK, Park KS. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Diabetes. 2004; 53(3):847–851.
29. Leońska-Duniec A, Cięszczyk P, Jastrzębski Z, Jażdżewska A, Lulińska-Kuklik E, Moska W, Ficek K, Niewczas M, Maciejewska-Skrendo A. The polymorphisms of the PPARD gene modify post-training body mass and biochemical parameter changes in women. PLoS ONE. 2018; 13(8): e0202557
30. Bordoni L, Marchegiani F, Piangerelli M, Napolioni V, Gabbianelli R. Obesity-Related Genetic Polymorphisms and Adiposity Indices in a Young Italian Population. IUBMB. 2017; 69(2):98–105 DOI 10.1002/iub.1596
31. dos Santos Rodrigues AP, Rosa LP, da Silva HD, de Paula Silveira-Lacerda E, Silveira EA. The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. J Obesity. 2018; https://doi. org/10.1155/2018/ 2743081
32. Chan KH, Niu T, Ma Y, You NY, Song Y, Sobel EM, Hsu Y, Balasubramanian R, Qiao Y, Tinker L, Liu S. Common Genetic Variants in Peroxisome Proliferator Activated Receptor-γ (PPARG) and Type 2 Diabetes Risk Among Women’s Health Initiative Postmenopausal Women. J Clin Endocrinol Metab. 2013; 98(3):E600–E604.
33. Hasan NS, Kamel SA, Hamed M, Awadallah E, Rahman EH, Musa NI, Hussein GH. Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus. J Genet Eng Biotechnol. 2017; 15:409–414.
34. Kruzliak P, Haley AP, Starcevic JN, Gaspar L, and Petrovic D. Polymorphisms of the Peroxisome Proliferator-Activated Receptor-γ (rs1801282) and its coactivator-1 (rs8192673) are associated with obesity indexes in subjects with type 2 diabetes mellitus. Cardiovasc Diabetol. 2015; 14:42
35. Rocha RM, Barra GB, Campos Caldas Rosa EC, Garcia EC, Amorim Amato A, Ferreira Azevedo M. Prevalence of the rs1801282 single nucleotide polymorphism of the PPARG gene in patients with metabolic syndrome. Arch Endocrinol Metab. 2015; 59/4.
36. Tellechea ML, Aranguren F, Pérez MS, Cerrone GE, Frechtel GD, Taverna MJ. Pro12Ala polymorphism of the peroxisome proliferator activated receptor-gamma gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: interaction with smoking status. Circ J. 2009; 73:2118–2124.
37. Leońska-Duniec A, Ahmetov Il, Żmijewski P. Genetic variants influencing effectiveness of exercise training programmes in obesity – an overview of human studies. Biol Sport. 2016; 33(3):207–214.
Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons Attribution Share Alike 4.0 License (https://creativecommons.org/licenses/by-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.
 
Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.