eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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SCImago Journal & Country Rank
3/2018
vol. 14
 
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abstract:
Original paper

Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease

Isa Sincer, Yilmaz Gunes, Asli Kurtar Mansiroglu, Mehmet Cosgun, Gulali Aktas

Adv Interv Cardiol 2018; 14, 3 (53): 263–269
Online publish date: 2018/09/21
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Introduction
The prognostic value of hematological indices in cardiovascular diseases and the association between these parameters and cardiovascular conditions have been established in the literature.

Aim
In this study, we aimed to investigate the relation of mean platelet volume (MPV), MPV to platelet ratio (MPR) and red cell distribution width (RDW) with degree of coronary collateral development (CCD) in stable coronary artery disease (CAD) subjects with established critical coronary artery stenosis.

Material and methods
A total of 306 patients with stable angina pectoris undergoing coronary arteriography were enrolled and divided on the basis of the development of CCD into two groups: a group with adequate CCD (n = 214) and a group with impaired CCD (n = 92). Routine complete blood count and biochemical parameters were measured before coronary arteriography.

Results
The MPV and MPR levels were significantly higher in the inadequate CCD group (10.5 ±1.8 fl vs. 8.7 ±1.9 fl, p < 0.001 and 0.06 ±0.08 vs. 0.05 ±0.07, p = 0.036). Patients with inadequate CCD had significantly higher RDW levels compared to patients with adequate CCD (15.5 ±1.7% vs. 15.0 ±1.9%, p = 0.01). MPV and RDW were significantly associated with Rentrop collateral grading (r = –0.523, p < 0.001 and r = –0.239, p < 0.001, respectively), whereas the association with MPR was not significant. An MPV value greater than 9.95 fl, determined with ROC curve analysis, had 71% sensitivity and 70% specificity in predicting inadequate CCD. An RDW greater than 14.3% has 71% sensitivity and 53% specificity in selecting patients with adequate CCD.

Conclusions
The present study suggests that MPV and MPR may be associated with the degree of collateral development in chronic stable CAD. However, the negative association of RDW with inadequate CCD, in combination with previous contradictory reports, raises a doubt about the possible value of RDW in stable CAD. Although these parameters may be affected by various conditions, a high MPV may lead clinicians to suspect possible inadequate collateral development in stable CAD patients.

keywords:

mean platelet volume, coronary collateral development, coronary artery disease, red cell distribution width, mean platelet volume to platelet ratio

references:
Çelik T, Çelik M, İyisoy A. Coronary collateral circulation. Turk J Cardiol 2010; 38: 505-14.
Sahin I, Karabulut A, Kaya A, et al. Increased level of red cell distribution width is associated with poor coronary collateral circulation in patients with stable coronary artery disease. Turk J Cardiol 2015; 43: 123-30.
Demirbag R, Gur M, Yilmaz R, et al. Influence of oxidative stress on the development of collateral circulation in total coronary occlusions. Int J Cardiol 2007; 116: 14-9.
Tsiara S, Elisaf M, Jagroop IA, et al. Platelets as predictors of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003; 9: 177-90.
Davì G, Patrono C. Platelet activation and atherothrombosis. New Eng J Med 2007; 357: 2482-94.
Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002; 13: 301-6.
Yilmaz MB, Cihan G, Guray Y, et al. Role of mean platelet volume in triagging acute coronary syndromes. J Thromb Thrombolysis 2008; 26: 49-54.
Ege MR, Acıkgoz S, Zorlu A, et al. Mean platelet volume: an important predictor of coronary collateral development. Platelets 2013; 24: 200-4.
Ornek E, Kurtul A. Relationship of mean platelet volume to lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris. Coron Artery Dis 2017; 28: 492-7.
Khandekar M, Khurana A, Deshmukh S, et al. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006; 59: 146-9.
Pekdemir H, Polat G, Cin VG, et al. Elevated plasma endothelin-1 levels in coronary sinus during rapid right atrial pacing in patients with slow coronary flow. Int J Cardiol 2004; 97: 35-41.
Cure MC, Cure E, Kirbas A, et al. The effects of Gilbert’s syndrome on the mean platelet volume and other hematological parameters. Blood Coagul Fibrinolysis 2013; 24: 484-8.
Ju HY, Kim JK, Hur SM, et al. Could mean platelet volume be a promising biomarker of progression of chronic kidney disease? Platelets 2015; 26: 143-7.
Cure E, Balik MS, Cumhur Cure M, et al. Is the mean platelet volume predictive of hip fractures in the elderly? Ann Lab Med 2013; 33: 367-70.
Azab B, Torbey E, Singh J, et al. Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets 2011; 22: 557-66.
Rentrop KP, Thornton JC, Feit F, et al. Determinants and protective potential of coronary arterial collaterals as assessed by an angioplasty model. Am J Cardiol 1988; 61: 677-84.
Habib G, Heibig J, Forman S, et al. Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I thrombolysis in myocardial infarction (TIMI) trial. The TIMI Investigators. Circulation 1991; 83: 739-46.
Meier P, Gloekler S, Zbinden R, et al. Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements. Circulation 2007; 116: 975-83.
Werner GS, Ferrari M, Heinke S, et al. Angiographic assessment of collateral connections in comparison with invasively determined collateral function in chronic coronary occlusions. Circulation 2003; 107: 1972-7.
Imhof BA, Aurrand-Lions M. Angiogenesis and inflammation face off. Nature Med 2006; 12: 171-2.
Gok M, Kundi H, Kiziltunc E, et al. Endocan levels and coronary collateral circulation in stable angina pectoris: a pilot study. Angiology 2018; 69: 43-8.
Açar G, Kalkan ME, Avci A, et al. The relation of platelet-lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion. Clin Appl Thromb Hemost 2015; 21: 462-8.
Kurtul A, Yarlioglues M, Murat SN, et al. Usefulness of the platelet-to-lymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Am J Cardiol 2014; 114: 342-7.
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Eng J Med 2003; 348: 138-50.
Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol 2006; 97: 993-6.
Braekkan S, Mathiesen E, Njølstad I, et al. Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study. J Thromb Haemost 2010; 8: 157-62.
Chung I, Choudhury A, Lip GY. Platelet activation in acute, decompensated congestive heart failure. Thrombosis Res 2007; 120: 709-13.
Thompson CB, Eaton KA, Princiotta SM, et al. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50: 509-19.
Bulur S, Önder HI, Aslantas Y, et al. Relation between indices of end-organ damage and mean platelet volume in hypertensive patients. Blood Coagul Fibrinolysis 2012; 23: 367-9.
Ranjith M, Divya R, Mehta V, et al. Significance of platelet volume indices and platelet count in ischaemic heart disease. J Clin Pathol 2009; 62: 830-3.
Tanboga IH, Topcu S, Nacar T, et al. Relation of coronary collateral circulation with red cell distribution width in patients with non-ST elevation myocardial infarction. Clin Appl Thromb Hemost 2014; 20: 411-5.
Perlstein TS, Weuve J, Pfeffer MA, et al. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch Intern Med 2009; 169: 588-94.
Martin J, Shaw T, Heggie J, et al. Measurement of the density of human platelets and its relationship to volume. Br J Haematol 1983; 54: 337-52.
Kamath S, Blann A, Lip G. Platelet activation: assessment and quantification. Eur Heart J 2001; 22: 1561-71.
Corash L, Tan H, Gralnick HR. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure. Blood 1977; 49: 71-87.
Ghaffari S, Pourafkari L, Javadzadegan H, et al. Mean platelet volume is a predictor of ST resolution following thrombolysis in acute ST elevation myocardial infarction. Thrombosis Res 2015; 136: 101-6.
Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol 2010; 15: 37-40.
Förhécz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state. Am Heart J 2009; 158: 659-66.
Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007; 50: 40-7.
Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163-8.
Sen HS, Abakay O, Tanrikulu AC, et al. Is a complete blood cell count useful in determining the prognosis of pulmonary embolism? Wien Klin Wochenschr 2014; 126: 347-54.
Li S, Salhany KE. Spurious elevation of automated platelet counts in secondary acute monocytic leukemia associated with tumor lysis syndrome. Arch Pathol Laboratory Med 1999; 123: 1111-4.
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