Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
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SCImago Journal & Country Rank
3/2019
vol. 36
 
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abstract:

Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program

Agata Leońska-Duniec
,
Krzysztof Ficek
,
Katarzyna Świtała
,
Paweł Cięszczyk

Biol Sport. 2019;36(3):291–296
Online publish date: 2019/08/14
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Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesityrelated traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p<0.001). Additionally, we revealed that participants with the GG genotype had a higher low-density lipoprotein cholesterol (LDL-C) level (p=0.046) during the entire study period. It could be concluded that harboring the GG genotype of rs1800629 may be considered to be a disadvantageous factor in the context of training-induced effects on lipid profile changes in young female participants.
keywords:

Sport genetics, TNF-α gene, Polymorphism, Physical activity, Lipid profile

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