eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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vol. 22
Review paper

Biomarkers could facilitate prediction of worse clinical outcome of cancer with special insight to cervical cancer

Bartosz Czerniak, Dorota Olszewska-Słonina

Contemp Oncol (Pozn) 2018; 22 (1): 1-7
Online publish date: 2018/04/03
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Cervical cancer incidence, globally, is second only to malignant breast cancer. The main causative factor is thought to be human papillomavirus (HPV) infection as a result of many sexual partners. Despite radiotherapy, chemotherapy and surgical treatment, the survival rate of patients with advanced disease is low. Metastasis is one of the stages of cancerogenesis in which tumour cells acquire the ability to migrate and create tumour secondary foci. Tumour biomarkers, proteins produced by neoplastic cells, quantified in body fluids or in tissues, play a key role in treatment monitoring and in determining the prognosis for further years of life. In recent years, the search for cervical cancer biomarkers has been intensively sought. They can become a decisive factor in making radical treatment and, in the near future, a potential therapeutic goal. The article presents and briefly describes the biomarkers of metastasis in cervical cancer studied in recent years and highlights their potential therapeutic use.

cervical cancer, metastasis, tumour biomarker, therapy, radio- and chemoresistance

Hou T, Liang D, Xu L, Huang X, Huang Y, Zhang Y. Atypical chemokine receptors predict lymph node metastasis and prognosis in patients with cervical squamous cell cancer. Gynecol Oncol 2013; 130: 181-7.
Song Z, Lin Y, Ye X, Feng C, Lu Y, Yang G, Dong C. Expression of IL-1and IL-6 is associated with progression and prognosis of human cervical cancer. Med Sci Monit 2016; 22: 4475-81.
Shen SN, Wang LF, Jia YF, Hao YQ, Zhang L, Wang H. Upregulation of microRNA-224 is associated with aggressive progression and poor prognosis in human cervical cancer. Diagnostic Pathology 2013; 8: 1-7.
Liu P, Xin F, Ma CF. Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer. Genet Mol Res 2015; 14: 17995-8002.
Cáceres G, Puskas JA, Magliocco AM. Circulating tumour cells: a window into tumour development and therapeutic effectiveness. Cancer Control 2015; 22: 167-76.
Gold B, Cankovic M, Furtado LV, Meier F, Gocke CD. Do circulating tumour cells, exosomes, and circulating tumour nucleic acids have clinical utility? A report of the association for molecular pathology. J Mol Diagn 2015; 17: 209-24.
Hu B, Niu X, Cheng L, Yang L, Li Q, Wang Y, Tao S, Zhou S. Discovering cancer biomarkers from clinical samples by protein microarrays. Proteomics Clin Appl 2015; 9: 98-110.
Shang C, Zhu W, Liu T, et al. Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncol Rep 2016; 35: 3185-97.
Cao S, Liu W, Li F, Zhao W, Qin C. Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer. Int J Clin Exp Pathol 2014; 7: 6776-83.
Jiang S, Wang HL, Yang J. Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer. Int J Clin Exp Pathol 2015; 8: 806-11.
Zhang J, Yao T, Wang Y, Yu J, Liu Y, Lin Z. Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating mir-21. Cancer Biol Ther 2016; 17: 104-13.
Chen Y, Wang CX, Sun XX, Wang C, Liu TF, Wang DJ. Long non-coding RNA CCHE1 overexpression predicts a poor prognosis for cervical cancer. Eur Rev Med Pharmacol Sci 2017; 20: 479-83.
Luo M, Shen D, Wang W, Xian J. Aberrant expression of microRNA-26b and its prognostic potential in human cervical cancer. Int
J Clin Exp Pathol 2015; 8: 5542-8.
Ma Q, Wan G, Wang S, Yang W, Zhang J, Yao X. Serum microRNA-205 as a novel biomarker for cervical cancer patients. Cancer Cell International 2014; 14: 1-7.
Lee H, Kim KR, Cho NH, et al. MicroRNA expression profiling and Notch1 and Notch2 expression in minimal deviation adenocarcinoma of uterine cervix. World J Surg Oncol 2014; 12: 1-9.
Hu Y, Xie H, Liu Y, Liu W, Liu M, Tang H. miR-484 suppresses proliferation and epithelial-mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells. Cancer Cell Int 2017; 17: 1-17.
Han Y, Xu GX, Lu H, et al. Dysregulation of miRNA-21 and their potential as biomarkers for the diagnosis of cervical cancer. Int J Clin Exp Pathol 2015; 8: 7131-9.
Chen J, Yao D, Li Y et, al. Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma. Int J Mol Med 2013; 32: 557-67.
Huang Y, Zhang J, Cui ZM, Zhao J, Zheng Y. Expression of the CXCL12/CXCR4 and CXCL16/CXCR6 axes in cervical intraepithelial neoplasia and cervical cancer. Chin J Cancer 2013; 32: 289-96.
Song Z, Zhang X, Ye X, Feng C, Yang G, Lu Y, Lin Y, Dong C. High expression of stromal cell-derived factor 1 (SDF-1) and NF-B predicts poor prognosis in cervical cancer. Med Sci Monit 2017; 23: 151-7.
Hou T, Liang D, Yang D, He J, Huang Y, Zhang Y. High expression of CRAM correlates with poor prognosis in patients with cervical carcinoma. Int J Clin Exp Pathol 2014; 7: 1060-68.
Tsai CC, Huang SC, Tai MH, Chien CCC, Huang CC, Hsu YC. Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma. Int J Mol Sci 2014; 15: 21492-504.
Zhou X, Xu CJ, Wang JX, et al. Metastasis-associated in colon cancer-1 associates with poor prognosis and promotes cell invasion and angiogenesis in human cervical cancer. Int J Gynecol Cancer 2015; 25: 1353-63.
Guo L, Lu W, Zhang X, Luo D, Zhang H. Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer. Int J Clin Exp Pathol 2014; 7: 4150-5.
Chang H, Shi Y, Tuokan T, Chen R, Wang X. Expression of aquaporin 8 and phosphorylation of Erk1/2 in cervical epithelial carcinogenesis: correlation with clinicopathological parameters. Int J Clin Exp Pathol 2014; 7: 3928-37.
Liu Y, Lin L, Huang Z, Ji B, Mei S, Lin Y, Shen Z. High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma. Int J Clin Exp Pathol 2015; 8: 622-8.
Wang W, Shi Y, Li J, Cui W, Yang B. Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer. Biosci Rep 2016; 36: 1-7.
Shen XJ, Gu K, Shi JP, Yao JQ, Wu JC. Increased expression of stanniocalcin 2 is associated with tumour progression after radiotherapy in patients with cervical carcinoma. Int J Clin Exp Pathol 2014; 7: 8770-8776.
Zhang W, Hou T, Niu C, Song L, Zhang Y. B3GNT3 expression is a novel marker correlated with pelvic lymph node metastasis and poor clinical outcome in early-stage cervical cancer. PLoS ONE 2015; 10: 1-20.
Liang SN, Huang YJ, Liu LL, Liu X. Study on the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma. Genet Mol Res 2015; 14: 8634-9.
Pang X, Zhang Y, Wei H, Zhang J, Luo Q, Huang C, Zhang S. Expression and effects of high-mobility group box 1 in cervical cancer. Int J Mol Sci 2014; 15: 8699-8712.
Wang S, Wang Le, Zhang Y, et al. Special AT-rich sequence-binding protein 1: a novel biomarker predicting cervical squamous cell carcinoma prognosis and lymph node metastasis. Japanese J Clin Oncol 2015; 45: 812-8.
Ouyang F, Liu J, Xia M, et al. GINS2 is a novel prognostic biomarker and promotes tumour progression in early-stage cervical cancer. Oncology Reports 2017; 37: 2652-62.
Huang K, Li LA, Meng Y, You Y, Fu X, Song L. High expression of astrocyte elevated gene-1 (AEG-1) is associated with progression of cervical intraepithelial neoplasia and unfavorable prognosis in cervical cancer. World Journal of Surgical Oncology 2013; 11: 1-7.
Shu XR, Wu J, Sun H, Chi LQ, Wang JH. PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway. Diagnostic Pathology 2015; 10: 1-9.
Ruan J, Mei L, Zhu Q, Shi G, Wang H. Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer. Int J Clin Exp Pathol 2015; 8: 15035-8.
Kim HS, Yoon G, Ryu JY, et al. Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer. Oncotarget 2015; 6: 26746-56.
Wang J, Ou J, Guo Y, et al. TBLR1 is a novel prognostic marker and promotes epithelial-mesenchymal transition in cervical cancer. Br J Cancer 2014; 111: 112-24.
Zhang Y, Liu B, Zhao Q, Hou T, Huang X. Nuclear localization of -catenin is associated with poor survival and chemo-/radioresistance in human cervical squamous cell cancer. Int J Clin Exp Pathol 2014; 7: 3908-17.
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