Botulinum toxin on a mission to erase keloids:
does the dream come true?

Aleksandra Fratczak; Aleksandra Spyra; Zuzanna Pawlus; Karina Polak; Beata Bergler-Czop

doi:10.5114/ada.2025.155421

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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5/2025
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abstract:

Review paper

Botulinum toxin on a mission to erase keloids: does the dream come true?

Aleksandra Fratczak

¹

,

Aleksandra Spyra

²

,

Zuzanna Pawlus

²

,

Karina Polak

¹

,

Beata Bergler-Czop

¹

Department of Dermatology, Medical University of Silesia, Katowice, Poland
Students’ Scientific Association at the Chair and Department of Dermatology, Medical University of Silesia, Katowice, Poland

Adv Dermatol Allergol 2025; XLII (5): 433–438

DOI: https://doi.org/10.5114/ada.2025.155421

Online publish date: 2025/10/20

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Keloids are fibrous scars that result from a variety of factors causing skin damage. Botulinum toxin, especially the most widely utilized serotype A, is used for many purposes in both medical and aesthetic practices. Numerous studies indicate the beneficial effects of using botulinum toxin in the treatment of scars, including keloids. The aim of this study was to explore the current evidence behind the use of botulinum toxin in the prevention and treatment of keloids. PubMed was searched using medical subject headings to identify studies on this topic. All analysed studies confirmed the effectiveness of intralesional injections of botulinum toxin in keloid therapy. Significant improvement in the appearance and size of lesions, histopathological findings, patient satisfaction, and reduction in symptoms are observed. Further research is required to ascertain the significance of this therapeutic approach in keloid treatment protocols.

keywords:

Botulinum toxin on a mission to erase keloids: does the dream come true?

Aleksandra Fratczak 1 , Aleksandra Spyra 2 , Zuzanna Pawlus 2 , Karina Polak 1 , Beata Bergler-Czop 1

keloids, botulinum toxin, keloid fibroblasts, keloid scar

Aleksandra Fratczak

¹

,

Aleksandra Spyra

²

,

Zuzanna Pawlus

²

,

Karina Polak

¹

,

Beata Bergler-Czop

¹