Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
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3/2025
vol. 63
 
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abstract:
Case report

Cerebellar lesions caused by vitamin B12 deficiency: a case report

Xin Hu
1
,
Hong Xu
1
,
Yang Han
1
,
Yan Wu
1
,
Li Fang
1
,
Li-Na Qin
1
,
Hong Miao
1
,
Li Chen
1
,
Ju-Ping Chen
1

  1. Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, China
Folia Neuropathol 2025; 63 (3): 320-326
DOI: https://doi.org/10.5114/fn.2025.152518
Online publish date: 2025/08/11
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Vitamin B12 deficiency can cause subacute combined degeneration of the spinal cord and cerebellar lesions. The patient, a 78-year-old woman, presented with an unstable gait, speech impairment and memory decline for one month. The neurological examination revealed ataxia, cerebellar speech disorder and mild cognitive impairment. Head and cervical vertebra magnetic resonance imaging (MRI) showed spinal cord and cerebellar lesions. The patient’s symptoms improved after supplementation with vitamin B12. We found few reports of such cases in the literature. In this case report, we describe the entire diagnostic and treatment process of vitamin B12 deficiency involving cerebellar lesions and briefly discuss the related pathogenesis, research progress and treatment.
keywords:

vitamin B12 deficiency, demyelination of the nervous system, cerebellum

  
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