eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2018
vol. 22
 
Share:
Share:
more
 
 
abstract:
Original paper

Changes in the chemical composition of mineralised teeth in children after antineoplastic treatment

Ewa Krasuska-Sławińska, Bożenna Dembowska-Bagińska, Agnieszka Brożyna, Dorota Olczak-Kowalczyk, Elżbieta Czarnowska, Agnieszka Sowińska

Contemp Oncol (Pozn) 2018; 22 (1): 37-41
Online publish date: 2018/04/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Chemotherapy, neoplasms, and their complications linked to malabsorption, malnutrition, and metabolic disorders may lead to improper tooth development and frequent severe caries in patients during/after antineoplastic treatment and to a more frequent improper tooth development in patients undergoing chemotherapy during odontogenesis. However, the causes of these abnormalities remain unknown; there are no studies on the impact of antineoplastic treatment and its complications on the chemical composition of mineralised teeth.

Aim of the study
To compare the chemical composition of mineralised teeth extracted due to complicated caries in children after chemotherapy, and of teeth extracted due to orthodontic treatment in generally healthy children.

Material and methods
The treatment group included five teeth extracted due to complicated caries in children after antineoplastic treatment. The control group included five teeth extracted due to orthodontic treatment in generally healthy children. The chemical composition of enamel, dentine, cementum, interior of the canal, and enamel abnormalities in teeth extracted from patients after chemotherapy and in generally healthy patients were assessed with energy-dispersive X-ray spectroscopy. Results were analysed statistically.

Results
The magnesium (Mg) and zinc (Zn) mass contents in the enamel of patients after chemotherapy increased and so did the calcium (Ca) to phosphorus (P) ratio when compared to controls. Areas with abnormal enamel in patients after chemotherapy had lower concentrations of Ca and P, and higher concentrations of trace elements (Mg, Cl, and Na). The levels of the assessed elements in dentine, cementum, and inside the canal were similar in both groups of teeth.

keywords:

children, chemotherapy, chemical composition of mineralised teeth

references:
Olczak-Kowalczyk D, Daszkiewicz M, Adamowicz-Klepalska B, Mielnik-Błaszczyk M, Dembowska-Bagińska B, Perek D. The status of dentition and oral hygiene in children after anticancer treatment. Ann Acad Med 2004; 34: 237-55.
Avşar A, Elli M, Darka O, Pinarli G. Long-term of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 781-9.
Maciel Cordova JC, de Castrojr CG, Brunatto Al Di Leone LP, da Silveira HE. Oral Health and dental abnormalies in patients treated for leukemia in childhood and adolescence. Pediatr Blood Cancer 2009; 53: 361-5.
Höltta P, Alaluusua S, Saarinen-Pihkala UM, Wolf J, Nystrom M, Hovi L. Long-term adverse effects on dentition in children with poor-risk neuroblastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation. Bone Marrow Transpl 2002; 29: 121-7.
Höltta P. Developmental aberrations of permanent teeth after high-dose anticancer therapy in childhood. Dissertation, Helsinki 2005.
Cubucku CE, Sevinir B, Ercan I. Disturbed dental development of permanent teeth in children with solid tumors and lymphomas. Pediatr Blood Cancer 2012; 58: 80-4.
Nemeth O, Hermann P, Kivovics P, Garami M. Long-term effects of chemotherapy on dental status of children cancer survivors. Pediatr Hematol Oncol 2013; 30: 208-15.
Fagrell TG, Dietz W, Jälevik B, Norén JG. Chemical, mechanical and morphological properties of hypomineralized enamel of permanent first molars. Acta Odontol Scand 2010; 68: 215-22.
Jalevik B, Odelius H, Dietz W, Noren J. Secondary ion mass spectrometry and X-ray microanalysis of hypomineralized enamel in human permanent molars. Arch Oral Biol 2001; 46: 239-47.
Ghadimi E, Eimar H, Marelli B, Nazhat SN, Asgharian M, Vali H, Tamimi F. Trace elements can influence the physical properties of tooth enamel. Springerplus 2013; 2: 499-53.
Shashikiran ND, Subba VV, Reddy Hiremath MC. Estamition of trace elements in sound and carious enamel of primary and permanent teeth by atomic absorption spectrophotometry: an in vitro study. Indian J Dent Res 2007; 18: 157-62.
Piesiak-Pańczyszyn D, Czajczyńska-Waszkiewicz A, Kaczmarek U. Comparative ultrastructure analysis of image and chemical components of early caries lesion and sound hard tissure of the teeth. Dent Med Probl 2005; 42: 443-8.
Pawlicki R, Knychalska-Karwan. Tooth hard-tissues of adults of different ages. Examinations in the scaning electron microscope and X-ray microanalyser. Czas Stomat 1994; 47: 672-80.
Knychalska-Karwan Z, Pawlicki R. Caries lesions of tooth smooth surfaces. SEM and rentgen microanalysator study. Magaz Stomat 1997; 8: 9-12.
Mazurek-Machol M, Machoy-Mokrzyńska A. The level of zinc in the blood, urine, bones and teeth of rets following intra-oral application of this element. Czas Stomat 2005; 58: 195-200.
Schalk-van der Weide Y, Steen WH, Bosman F. Taurodontizm and lengh of teeth with patients with ologodontia. J Oral Rehabil 1993; 20: 401-12.
Amr M, Fattah A, Helal I. Analysis of trace elements in teeth by IPC-MS implications for caries. J Phys Sci 2010; 21: 1-12.
Opalko K, Łagocka R, Marczuk-Kolada G, Stokowska W. Magnesium content in permanent dental enamel in children from Bialystok and Szczecin (in vitro studies). Nowa Stomat 1999; 4: 15-17.
Gomes VE, Wada RS, Cury AJ, Rosario de Sousa ML. Lead level, enamel defects and dental caries in deciduous teeth. Rev Saude Publica 2004; 38: 1-6.
Matthers-Brzozowska T, Surdacka A, Kobylańska M, Jóźwiak K, Stachecki B. Remineralisation of induced enamel defects in vivo study. Czas Stomat 1991; 44: 251-7.
Dowker SEP, Anderson P, Elliott JC, Gao XJ. Crystal chemistry and dissolution of calcium phosphate in dental enamel. Mineralog Magaz 1999; 63: 791-800.
Magnus L, Maltz M, Baveresco C, Bastos LF, Hashizume L. Biochemical composition of carious dentin and different layers of sound dentin. J Oral Sci 2013; 55: 133-7.
Brodzikowska A. X-ray microanalysis of carious lesion in the root cement following application of Fluor Protector fluoride varnish and Cervitac chlorhexidine varnish. Czas Stomat 2005; 58: 167-74.
Macleod RI, Welbury RR, Soames JV. Effects of cytotoxic chemotherapy on dental development. J Royal Soc Med 1987; 80: 207-9.
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe