Liver and bile duct diseases such as gallstone, liver steatosis, alcoholic liver disease, and drug-induced liver injury are common and increasing problem in General Practice. Abnormal liver blood results are the first symptoms that may suggest dysfunction or damage of liver. Early detection of malignant liver diseases is still a problem, whereas the key factor is the prevention of hepatocyte apoptosis and further development of liver diseases. Nowadays, many of liver diseases can be treated by the administration of UDCA.