Clinical follow-up studies of a family with an aggregation of arthritis and extra-articular symptoms

Irena Zimmermann-Górska; Ewa Bornakowska-Zabel; Olga Zabłotna

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

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5/2009
vol. 47

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abstract:

Original paper

Clinical follow-up studies of a family with an aggregation of arthritis and extra-articular symptoms

Irena Zimmermann-Górska

,

Ewa Bornakowska-Zabel

,

Olga Zabłotna

Reumatologia 2009; 47, 5: 258-267

Online publish date: 2009/12/29

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Acute, recurrent, seronegative oligoarthritis starting in childhood is observed in two consecutive generations of the same family (in 12 cases). Extra-articular symptoms are also observed: hepato-and/or splenomegaly, myocarditis, frequent infections as well as high values of ESR and CRP and decreased haemoglobin level. In some patients there occurred leucopenia, hypergam-maglobulinaemia and haematuria. HLA-B27 was negative in all members of the family. Histological examination of synovium, performed in 3 cases after synovectomy, yielded an atypical picture. The described syndrome does not correspond to the criteria of any definite rheumatic disease.

keywords:

arthritis, familial aggregation

EVENTS/KONFERENCJE

BOOKS/KSIĄŻKI

Clinical follow-up studies of a family with an aggregation of arthritis and extra-articular symptoms

Irena Zimmermann-Górska , Ewa Bornakowska-Zabel , Olga Zabłotna

arthritis, familial aggregation

Irena Zimmermann-Górska

,

Ewa Bornakowska-Zabel

,

Olga Zabłotna