eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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vol. 4

Clinical research
B-type natriuretic peptide level in adult patients after successful repair of coarctation of the aorta

Olga Trojnarska
Piotr Bręborowicz
Adrian Gwizdała
Małgorzata Pyda
Zofia Oko-Sarnowska
Andrzej Szyszka
Stefan Grajek

Arch Med Sci 2008; 4, 3: 274–277
Online publish date: 2008/10/15
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Introduction: The aim of the study was to evaluate BNP in adults after successful surgery of CoAo.
Material and methods: Seventy-four patients after surgery of CoAo entered the study group aged 31.2±9.8 and operated at age 10.4±6.8. The control group consisted of 30 healthy volunteers (18 males) aged 32.2±6.6. 2D and Doppler echocardiography was performed. Patients were divided into two groups: with or without DAo restenosis. All patients underwent an exercise treadmill test. Patients were enrolled in the study if they were found to have untreated HT or if a two-week cessation of hypotensive therapy was possible. In all cases BNP level was measured.
Results: 32 patients showed normal BP while 10 had exercise-induced HT. The remaining patients had chronic HT. The maximal systolic gradient in DAo was comparable in all groups. In 33 patients residual DAo stenosis was noted (DAo+) 36.6±9.8 mm Hg, and in another 41 it was not (DAo–) 15.9±5.1. The maximal transvalvular aortic pressure gradient was 11.7±6.2 mm Hg. BNP in the study group was higher than among controls, though it was higher in the DAo+ subgroup than in the DAo– subgroup. BNP level also correlated with patients’ age at the time of operation (R=0.275, P=0.02), and with transaortic gradient (R=0.233, P=0.04).
Conclusions: BNP in adults after CoAo repair is significantly elevated, which may be due to the pressure load of LV.

BNP, heart failure, GUCH, coarctation of the aorta

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