eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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vol. 4

Clinical research
Small dense LDL cholesterol and apolipoproteins C-II and C-III in non-diabetic obese subjects with metabolic syndrome

Theodosios D. Filippatos
Vasilis Tsimihodimos
Michalis Kostapanos
Christina Kostara
Eleni T. Bairaktari
Dimitrios N. Kiortsis
Alexandros D. Tselepis
Moses S. Elisaf

Arch Med Sci 2008; 4, 3: 263–269
Online publish date: 2008/10/15
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Introduction: Apolipoprotein (apo) C-II is considered as an important activator of lipoprotein lipase (LPL) and is required for efficient lipolysis of triglyceride (TG)-rich lipoproteins. In contrast, excess apo C-II inhibits LPL-mediated hydrolysis of TGs. Apo C-III is an inhibitor of LPL activity. These effects may influence the plasma levels of atherogenic small dense low-density lipoprotein cholesterol (sdLDL-C), since TG concentrations are markers of this subfraction.
Material and methods: We examined the possible influence of apo C-II and C-III plasma levels on sdLDL-C concentration in obese patients with metabolic syndrome (MetS). Plasma apo C-II and C-III were determined by an immunoturbidimetric assay. Obese subjects (n=73) with MetS but without any clinically evident cardiovascular disease were enrolled.
Results: TG, apo C-II and C-III plasma levels progressively increased when study participants were divided according to sdLDL-C tertiles (P<0.001 for all 3 trends). The apo C-III/C-II ratio was relatively constant (i.e. »2.5) for all tertiles of sdLDL-C. Stepwise multiple linear regression analyses showed that apo C-III levels independently correlated with TG levels, while TG and apo B levels were independently associated with sdLDL-C concentrations. Apo C-II and C-III significantly correlated with sdLDL-C in univariate analysis, but not in multivariate analysis.
Conclusions: Apo C-II and C-III levels are not independent predictors of sdLDL-C levels in obese subjects with MetS.

metabolic syndrome, apolipoprotein C-II, apolipoprotein C-III, small dense LDL, triglycerides, obesity

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