Folia Neuropathologica
eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
2/2025
vol. 63
 
Share:
Send email
Share:
abstract:
Case report

Clinicopathological and neuroradiological presentation in an immuno-deficiency patient with central nervous system recurrence of Burkitt lymphoma: an extremely rare case with complete remission achieved twice after GMALL-B-ALL/NHL2002 and R-MIV protocols

Piotr Glinka
1
,
Michał Sobstyl
1
,
Grzegorz Rymkiewicz
2
,
Karol Karamon
3
,
Monika Skowronek-Płachta
3
,
Albert Acewicz
4
,
Katarzyna Błachnio
2
,
Robert Konecki
5
,
Marcin Chmielewski
2

  1. Department of Neurosurgery, Institute of Psychiatry and Neurology, Warsaw, Poland
  2. Flow Cytometry Laboratory, Department of Cancer Pathomorphology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
  3. Department of Radiology, Institute of Psychiatry and Neurology, Warsaw, Poland
  4. Department of Neuropathology, Institute of Psychiatry and Neurology, Warsaw, Poland
  5. Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
Folia Neuropathol 2025; 63 (2): 198-208
DOI: https://doi.org/10.5114/fn.2025.152574
Online publish date: 2025/07/04
View full text Get citation
 
PlumX metrics:
Burkitt lymphoma (BL) is a specific, rare (1-2% of all cases of lymphoma) and aggressive type of B-cell non-Hodgkin lymphoma. If BL recurs during treatment, it usually becomes drug-resistant to subsequent treatment regimens and the prognosis is very poor. We present an extremely rare case of recurrent BL infiltrating the central nervous system (CNS) in a 27-year-old HIV-infected patient who had completed GMALL-B-ALL/NHL2002 protocol treatment 4 months earlier. Radiological and neuropathological examinations of cerebral recurrence of BL, followed by specialized oncological treatment, were discussed. Currently, with antiretroviral therapy and intensive immunochemotherapy for the immunodeficiency-associated BL variant, disease recurrence in the CNS is extremely rare. The magnetic resonance imaging (MRI) findings and laboratory tests are unspecific, as shown in the present case. The final diagnosis can be established properly by performing image-guided stereotactic biopsy or flow cytometry with cytology examination of cerebrospinal fluid. After confirmation of isolated cerebral recurrence of BL, the patient received intensive treatment according to the R-MIV protocol and achieved a second complete remission.
keywords:

Burkitt lymphoma, immunodeficiency-associated Burkitt lymphoma, brain tumor, GMALL-B-ALL/NHL2002 protocol, R-MIV protocol, stereotactic biopsy

  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2025 Termedia Sp. z o.o.
Developed by Bentus.