eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 40
Original paper

Compositional differences between gut microbiota of adult patients with asthma and healthy controls

Arkadiusz Hoffmann
Tadeusz Strózik
Tomasz Wasiak
Krzysztof Buczyłko
Rafał Pawliczak

Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
Departament of Molecular Biology, Faculty of Medicine, Medical University of Lodz, Lodz, Poland
State University of Applied Sciences in Wloclawek, Wloclawek, Poland
Adv Dermatol Allergol 2023; XL (1): 142-149
Online publish date: 2022/07/10
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Asthma is a complex and multifactorial disorder, with severe public health implications. Over the last several years, our knowledge in the field of human gut microbiota has expanded and allowed us to understand its crucial role in the development of many diseases.

To analyse the nature of human gut microbiota patterns among patients with asthma compared to healthy controls.

Material and methods:
Composition of the complex gut microbiota was analysed in faecal samples from 13 asthma patients and 7 healthy volunteers using Next-Generation Sequencing technology (NGS). The Kruskal-Wallis Analysis of Variance (ANOVA) and Mann-Whitney tests were used to compare the above two groups of subjects.

The composition of the gut microbiota of asthma patients differed from that of healthy volunteers at each of the analysed levels (p < 0.05). Compared to healthy individuals, bacterial diversity was significantly lowered among the asthma group, which is the evidence of gut microbiota depletion in asthma patients. The analysis of beta diversity showed that the gut community compositions of asthma are widely dispersed in contrast to the tight clustering observed in the control group. Finally, the similarity index was found to be lower in the inter-group comparison than in the intra-group comparison, which confirmed changes in the gut microbial composition in the asthmatic group.

The study revealed significant differences in the human gut microbiome composition between asthma patients and the healthy control group.


asthma, gut microbiota, Next-Generation Sequencing, gut microbiome

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