eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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4/2016
 
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Coronary artery spasm following on-pump coronary artery bypass grafting with 20 months follow-up

Adam R. Kowalówka, Marcin Malinowski, Magdalena Onyszczuk, Marek Deja

Kardiochirurgia i Torakochirurgia Polska 2016; 13 (4): 361-365
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Case report

We report a case of a 69-year-old non-smoking woman after ST-elevation myocardial infarction with stent implantation in the left artery descending (LAD) 11 years ago. No peripheral blood vessel diseases, such as Raynaud’s phenomenon, were present in the patient’s medical history. The patient presented with exertional angina despite optimal medical treatment. Admission coronary angiogram (CAG) showed ostial stenosis of LAD (70%), proximal obtuse marginal artery (OM) (70%), right coronary artery (RCA) segment 2 (60%) and ostial posterior descending artery (PDA) (70%). Preoperative echocardiography confirmed good left ventricle ejection fraction (50%). Coronary artery bypass grafting (CABG) procedure was performed with a saphenous vein graft to the PDA and a composite Y vein graft to the OM and LAD. The left internal thoracic artery (LITA) was harvested but not used as no satisfactory flow could be obtained. No injury or dissection of the LITA was observed. Lack of flow probably resulted from arterial spasm. The flow in coronary grafts was not assessed as the weaning from the cardiopulmonary bypass (CPB) was uneventful. The patient returned to the intensive care unit (ICU) in a stable condition on dopamine. In the immediate postoperative period, ECG showed ST-segment elevation in leads II, III, aVF and depression in leads V1–V3 (Fig. 1 A). Then the intra-aortic balloon pump (IABP) was inserted at the ICU, but the electrocardiogram (ECG) abnormalities did not disappear. The patient was transferred immediately to the catheter laboratory. Two hours after the CABG troponin T was 0.122 ng/ml and creatine kinase (CK)-MBmass 41 µg/ml. CAG revealed diffuse severe triple-vessel coronary artery spasm (CAS) (Figs. 2 A, C, 3 A, C). Systemic and direct infusion of nitroglycerine into the coronary arteries and grafts alleviated the spasm (Figs. 2 B, 2 D, 3 B, 3 D). Changes in the ECG disappeared (Fig. 1 B). On the next day the troponin T level was 0.380 ng/ml. Echocardiography showed an ejection fraction of 55%. The IABP was discontinued on postoperative day two. The patient was transferred in good condition to the cardiac unit on the ninth postoperative day and remains symptom-free at 20 months follow-up (Figs. 4 A, B, C).
The CAS after CABG is a rare (0.8–1.3%) but life-threatening complication with high morbidity and mortality [1]. It can occur during surgery or in the immediate postoperative period. It may involve manipulated or non-manipulated vessels, an implanted graft or native coronary arteries [2], but the RCA is most commonly involved [1]. The etiology of CAS after CABG is still undetermined, but several factors could induce vasospasm: vascular damage, oxidative stress, high levels of administered or endogenous vasoconstrictors, electrolyte abnormalities (hypomagnesaemia, hyperkalaemia), hypothermia, hypocapnia, preoperative use of β-blocking agents, calcium channel blockers (CCB) and high dosage of nitroglycerine [3]. Postoperative CAS is most commonly manifested by ST-segment elevation, hemodynamic instability, arrhythmia, circulatory collapse or cardiac arrest [3]. The gold standard for revealing CAS is CAG [4]. The best treatment for CAS is intravenous injection of vasodilator agents such as isosorbide dinitrate, adenosine triphosphate, papaverine, nicorandil and CCB. Several studies have reported that stent implantation is an option in cases of refractory CAS with focal lesions, but it is associated with many complications. The CAS is difficult to establish in patients hemodynamically. Preoperative recognition of high-risk patients, avoiding manipulation of the heart to minimize surgical trauma, minimizing the use of the carbon dioxide blower and avoiding hypothermia have all been proposed for the prevention of CAS. Postoperatively infusion of nitroglycerine, calcium antagonists and supplemental magnesium may decrease the risk of CAS [1].

Disclosure

Authors report no conflict of interest.

References

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2. Lorusso R, Crudeli E, Lucà F, De Cicco G, Vizzardi E, D’Aloia A, Gelsomino S. Refractory spasm of coronary arteries and grafted conduits after isolated coronary artery bypass surgery. Ann Thorac Surg 2012; 93: 545-551.
3. Baek JH, Han SS, Lee DH. Native coronary artery and grafted artery spasm just after coronary artery bypass grafting: a case report. J Korean Med Sci 2010; 25: 641-643.
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Copyright: © 2016 Polish Society of Cardiothoracic Surgeons (Polskie Towarzystwo KardioTorakochirurgów) and the editors of the Polish Journal of Cardio-Thoracic Surgery (Kardiochirurgia i Torakochirurgia Polska). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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