eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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SCImago Journal & Country Rank
2/2023
vol. 19
 
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abstract:
Original paper

Corrected QT interval in electrocardiogram recordings in patients treated with calcium channel blockers

Małgorzata Wołek
1, 2
,
Katarzyna Matusiak
1
,
Patryk Machoczek
3
,
Łukasz Partyka
2, 4
,
Wojciech Zasada
2, 5

1.
Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland
2.
KCRI Krakow, Poland
3.
Faculty of Mechanical Engineering and Robotics, AGH University of Science and Technology, Krakow, Poland
4.
Department of Angiology, University Hospital, Krakow, Poland
5.
Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland
Adv Interv Cardiol 2023; 19, 2 (72): 171–177
Online publish date: 2023/06/30
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Introduction:
One of the most popular tests of the heart is the electrocardiogram (ECG). The physical basis of this study has been known for over 200 years. However, the way an ECG is performed and the interpretation of the obtained results have undergone considerable evolution over time.

Aim:
To analyze the ECG recordings regarding the QTc interval in patients taking calcium channel blockers.

Material and methods:
The publicly available PhysioNet signals database was used to analyze the effect of selected drugs on the heart rhythm and QTc interval. To automate the QTc assessment, the database was processed in MATLAB. First, QTc was assessed using four formulas; then the results were compared in terms of methodology and medications taken.

Results:
In the group of patients taking dihydropyridine blockers, the QTc interval assessed by the Bazett formula (mean: 478.87 ms; SD: 73.10) is longer than in patients taking non-dihydropyridine blockers (mean: 446.54 ms, SD: 88.07, p = 0.2123) and in patients not taking calcium channel blockers (mean: 436.33 ms, SD: 49.94, p = 0.0319). The same significant differences were obtained regardless of the QTc assessment method used. However, the QTc result obtained with the Bazett formula is significantly lower than in the case of using the other three formulas used for the presented analysis.

Conclusions:
Automatic ECG analysis is possible; however, it should be used carefully, considering the possibility of obtaining incorrect results. Taking calcium channel blockers may affect the QTc interval. QTc results significantly depend on the formula based on which we evaluate this parameter.

keywords:

QTc, calcium channel blockers, electrocardiogram

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