1. Asadi-Pooya AA, Rostamihosseinkhani M, Farazdaghi M. Seizure and social outcomes in patients with non-surgically treated temporal lobe epilepsy. Epilepsy Behav 2021; 122: 108227.
2.
Berg AT, Zelko FA, Levy SR, Testa FM. Age at onset of epilepsy, pharmacoresistance, and cognitive outcomes: a prospective cohort study. Neurology 2012; 79: 1384-1391.
3.
Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361: 31-39.
4.
Cao J, Tang C, Gao M, Rui Y, Zhang J, Wang L, Wang Y, Xu B, Yan BC. Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy. J Ethnopharmacol 2020; 257: 112884.
5.
Chen S, Lv K, Sharda A, Deng J, Zeng W, Zhang C, Hu Q, Jin P, Yao G, Xu X, Ming Z, Fang C. Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection. Pharmacol Res 2021; 167: 105540.
6.
Cheng QC, Fan J, Deng XW, Liu HC, Ding HR, Fang X, Wang JW, Chen CH, Zhang WG. Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis. World J Gastroenterol 2020; 26: 6346-6360.
7.
Cooke SF, Bliss TV. Plasticity in the human central nervous system. Brain 2006; 129 (Pt 7): 1659-1673.
8.
Cristina de Brito Toscano E, Leandro Marciano Vieira É, Boni Rocha Dias B, Vidigal Caliari M, Paula Gonçalves A, Varela Giannetti A, Maurício Siqueira J, Kimie Suemoto C, Elaine Paraizo Leite R, Nitrini R, Alvarenga Rachid M, Lúcio Teixeira A. NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-b in sclerotic hippocampi. Brain Res 2021; 1752: 147230.
9.
Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O’Neill LAJ, Lynch MA. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-b and cognitive function in APP/PS1 mice. Brain Behav Immun 2017; 61: 306-316.
10.
Ding Y, Gong W, Zhang S, Shen J, Liu X, Wang Y, Chen Y, Meng G. Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation. Biochem Pharmacol 2021; 192: 114665.
11.
Fan Z, Pan YT, Zhang ZY, Yang H, Yu SY, Zheng Y, Ma JH, Wang XM. Systemic activation of NLRP3 inflammasome and plasma a-synuclein levels are correlated with motor severity and progression in Parkinson’s disease. J Neuroinflammation 2020; 17: 11.
12.
Feng J, Wang JX, Du YH, Liu Y, Zhang W, Chen JF, Liu YJ, Zheng M, Wang KJ, He GQ. Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice. CNS Neurosci Ther 2018; 24: 1207-1218.
13.
Feng YS, Tan ZX, Wang MM, Xing Y, Dong F, Zhang F. Inhibition of NLRP3 inflammasome: A prospective target for the treatment of ischemic stroke. Front Cell Neurosci 2020; 14: 155.
14.
Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73: 1907-1916.
15.
Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT. b-amyloid clustering around ASC fibrils boosts its toxicity in microglia. Cell Rep 2020; 30: 3743-3754.e6.
16.
Geng J, Zhao H, Liu X, Geng J, Gao Y, He B. MiR-101a-3p attenuated pilocarpine-induced epilepsy by downregulating c-FOS. Neurochem Res 2021; 46: 1119-1128.
17.
Girardi-Schappo M, Fadaie F, Lee HM, Caldairou B, Sziklas V, Crane J, Bernhardt BC, Bernasconi A, Bernasconi N. Altered communication dynamics reflect cognitive deficits in temporal lobe epilepsy. Epilepsia 2021; 62: 1022-1033.
18.
Guo L, Bai G, Zhang H, Lu D, Zheng J, Xu G. Cognitive functioning in temporal lobe epilepsy: A BOLD-fMRI study. Mol Neurobiol 2017; 54: 8361-8369.
19.
Hou XL, Tong Q, Wang WQ, Shi CY, Xiong W, Chen J, Liu X,
20.
Fang JG. Suppression of inflammatory responses by dihydromyricetin, a flavonoid from ampelopsis grossedentata, via inhibiting the activation of NF-kB and MAPK signaling pathways. J Nat Prod 2015; 78: 1689-1696.
21.
Hwang G, Dabbs K, Conant L, Nair VA, Mathis J, Almane DN, Nencka A, Birn R, Humphries C, Raghavan M, DeYoe EA, Struck AF, Maganti R, Binder JR, Meyerand E, Prabhakaran V, Hermann B. Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy. Cortex 2019; 117: 41-52.
22.
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT. NLRP3 inflammasome activation drives tau pathology. Nature 2019; 575: 669-673.
23.
Kou X, Liu X, Chen X, Li J, Yang X, Fan J, Yang Y, Chen N. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway. Oncotarget 2016; 7: 74484-74495.
24.
Lentini C, d’Orange M, Marichal N, Trottmann MM, Vignoles R, Foucault L, Verrier C, Massera C, Raineteau O, Conzelmann KK, Rival-Gervier S, Depaulis A, Berninger B, Heinrich C. Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy. Cell Stem Cell 2021; 28: 2104-2121.e10.
25.
Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, Moynagh PN, Wang B, Hu G, Yang S. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med 2019; 216: 2562-2581.
26.
Li Z, Ali I, Qiu J, Zhao H, Ma W, Bai A, Wang D, Li J. Eco-friendly and facile synthesis of antioxidant, antibacterial and anticancer dihydromyricetin-mediated silver nanoparticles. Int J Nanomedicine 2021; 16: 481-492.
27.
Liu B, Kou J, Li F, Huo D, Xu J, Zhou X, Meng D, Ghulam M, Artyom B, Gao X, Ma N, Han D. Lemon essential oil ameliorates age-associated cognitive dysfunction via modulating hippocampal synaptic density and inhibiting acetylcholinesterase. Aging (Albany NY) 2020; 12: 8622-8639.
28.
Liu CM, Yang W, Ma JQ, Yang HX, Feng ZJ, Sun JM, Cheng C, Jiang H. Dihydromyricetin inhibits lead-induced cognitive impairments and inflammation by the adenosine 5’-monophosphate-activated protein kinase pathway in mice. J Agric Food Chem 2018; 66: 7975-7982.
29.
Liu M, Guo H, Li Z, Zhang C, Zhang X, Cui Q, Tian J. Molecular level insight into the benefit of myricetin and dihydromyricetin uptake in patients with Alzheimer’s diseases. Front Aging Neurosci 2020; 12: 601603.
30.
Liu TT, Zeng Y, Tang K, Chen X, Zhang W, Xu XL. Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice. Atherosclerosis 2017; 262: 39-50.
31.
Magee JC, Grienberger C. Synaptic plasticity forms and functions. Annu Rev Neurosci 2020; 43: 95-117.
32.
Malhotra S, Costa C, Eixarch H, Keller CW, Amman L, Martínez-Banaclocha H, Midaglia L, Sarró E, Machín-Díaz I, Villar LM, Triviño JC, Oliver-Martos B, Parladé LN, Calvo-Barreiro L,
33.
Matesanz F, Vandenbroeck K, Urcelay E, Martínez-Ginés ML, Tejeda-Velarde A, Fissolo N, Castilló J, Sanchez A, Robertson AAB, Clemente D, Prinz M, Pelegrin P, Lünemann JD, Espejo C, Montalban X, Comabella M. NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. Brain 2020; 143: 1414-1430.
34.
Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev 2017; 277: 61-75.
35.
Martínez-Coria H, Mendoza-Rojas MX, Arrieta-Cruz I, López-Valdés HE. Preclinical research of dihydromyricetin for brain aging and neurodegenerative diseases. Front Pharmacol 2019; 10: 1334.
36.
Mátyás A, Borbély E, Mihály A. Hippocampal sclerosis in pilocarpine epilepsy: Survival of peptide-containing neurons and learning and memory disturbances in the adult NMRI strain mouse. Int J Mol Sci 2021; 23: 204.
37.
Mohseni-Moghaddam P, Roghani M, Khaleghzadeh-Ahangar H, Sadr SS, Sala C. A literature overview on epilepsy and inflammasome activation. Brain Res Bull 2021; 172: 229-235.
38.
Nicoll RA. A brief history of long-term potentiation. Neuron 2017; 93: 281-290.
39.
Parsons ALM, Bucknor EMV, Castroflorio E, Soares TR, Oliver PL, Rial D. The interconnected mechanisms of oxidative stress and neuroinflammation in epilepsy. Antioxidants (Basel) 2022; 11: 157.
40.
Pracucci E, Pillai V, Lamers D, Parra R, Landi S. Neuroinflammation: A signature or a cause of epilepsy? Int J Mol Sci 2021; 22: 6981.
41.
Qi S, Xin Y, Guo Y, Diao Y, Kou X, Luo L, Yin Z. Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-kB signaling pathways. Int Immunopharmacol 2012; 12: 278-287.
42.
Qian J, Wang X, Cao J, Zhang W, Lu C, Chen X. Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation. Neurosci Lett 2021; 756: 135963.
43.
Rashid S, Wali AF, Rashid SM, Alsaffar RM, Ahmad A, Jan BL, Paray BA, Alqahtani SMA, Arafah A, Rehman MU. Zingerone targets status epilepticus by blocking hippocampal neurodegeneration via regulation of redox imbalance, inflammation and apoptosis. Pharmaceuticals (Basel) 2021; 14: 146.
44.
Ren E, Curia G. Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy. Int J Mol Sci 2021; 22: 3860.
45.
Reyes A, Kaestner E, Edmonds EC, Christina Macari A, Wang ZI, Drane DL, Punia V, Busch RM, Hermann BP, McDonald CR; Alzheimer’s disease neuroimaging initiative. Diagnosing cognitive disorders in older adults with epilepsy. Epilepsia 2021; 62: 460-471.
46.
Sorg AL, von Kries R, Borggraefe I. Cognitive disorders in childhood epilepsy: a comparative longitudinal study using administrative healthcare data. J Neurol 2022; 269: 3789-3799.
47.
Sultana B, Panzini MA, Veilleux Carpentier A, Comtois J, Rioux B, Gore G, Bauer PR, Kwon CS, Jetté N, Josephson CB, Keezer MR. Incidence and prevalence of drug-resistant epilepsy: A systematic review and meta-analysis. Neurology 2021; 96: 805-817.
48.
Sun CC, Yin ZP, Chen JG, Wang WJ, Zheng GD, Li JE, Chen LL, Zhang QF. Dihydromyricetin improves cognitive impairments in d-galactose-induced aging mice through regulating oxidative stress and inhibition of acetylcholinesterase. Mol Nutr Food Res 2022; 66: e2101002.
49.
Sun Y, Liu S, Yang S, Chen C, Yang Y, Lin M, Liu C, Wang W, Zhou X, Ai Q, Wang W, Chen N. Mechanism of dihydromyricetin on inflammatory diseases. Front Pharmacol 2022; 12: 794563.
50.
Sun Z, Lu W, Lin N, Lin H, Zhang J, Ni T, Meng L, Zhang C, Guo H. Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1. Biochem Pharmacol 2020; 175: 113888.
51.
Sweatt JD. Neural plasticity and behavior – sixty years of conceptual advances. J Neurochem 2016; 139 Suppl 2: 179-199.
52.
Symonds JD, Zuberi SM, Stewart K, McLellan A, O’Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M. Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort. Brain 2019; 142: 2303-2318.
53.
Tai XY, Bernhardt B, Thom M, Thompson P, Baxendale S, Koepp M, Bernasconi N. Review: Neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: Clinical, pathological and neuroimaging evidence. Neuropathol Appl Neurobiol 2018; 44: 70-90.
54.
Tang N, Ma J, Wang KS, Mi C, Lv Y, Piao LX, Xu GH, Li X, Lee JJ, Jin X. Dihydromyricetin suppresses TNF-a-induced NF-kB activation and target gene expression. Mol Cell Biochem 2016; 422: 11-20.
55.
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, Yu Y, Gao F. a-synuclein promotes progression of Parkinson’s disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome. Exp Ther Med 2020; 19: 931-938.
56.
Wang Z, Zhou L, An D, Xu W, Wu C, Sha S, Li Y, Zhu Y, Chen A, Du Y, Chen L, Chen L. TRPV4-induced inflammatory response is involved in neuronal death in pilocarpine model of temporal lobe epilepsy in mice. Cell Death Dis 2019; 10: 386.
57.
Watanabe S, Omran AA, Shao AS, Xue C, Zhang Z, Zhang J, Davies DL, Shao XM, Watanabe J, Liang J. Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice. Sci Rep 2022; 12: 5899.
58.
Wei C, Chen X, Chen D, Yu B, Zheng P, He J, Chen H, Yan H, Luo Y, Huang Z. Dihydromyricetin enhances intestinal antioxidant capacity of growing-finishing pigs by activating ERK/Nrf2/HO-1 signaling pathway. Antioxidants (Basel) 2022; 11: 704.
59.
Xia S, Yang P, Li F, Yu Q, Kuang W, Zhu Y, Lu J, Wu H, Li L, Huang H. Chaihu-Longgu-Muli Decoction exerts an antiepileptic effect in rats by improving pyroptosis in hippocampal neurons. J Ethnopharmacol 2021; 270: 113794.
60.
Xu P, Hong Y, Xie Y, Yuan K, Li J, Sun R, Zhang X, Shi X, Li R, Wu J, Liu X, Hu W, Sun W. TREM-1 exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental subarachnoid hemorrhage. Transl Stroke Res 2021; 12: 643-659.
61.
Yang N, Guan QW, Chen FH, Xia QX, Yin XX, Zhou HH, Mao XY. Antioxidants targeting mitochondrial oxidative stress: Promising neuroprotectants for epilepsy. Oxid Med Cell Longev 2020; 2020: 6687185.
62.
Yu S, Gu Y, Wang T, Mu L, Wang H, Yan S, Wang A, Wang J, Liu L, Shen H, Na M, Lin Z. Study of neuronal apoptosis ceRNA network in hippocampal sclerosis of human temporal lobe epilepsy by RNA-Seq. Front Neurosci 2021; 15: 770627.
63.
Zhang Q, Wang J, Zhang H, Zeng T. Dihydromyricetin inhibits oxidative stress and apoptosis in oxygen and glucose deprivation/reoxygenation induced HT22 cells by activating the Nrf2/HO 1 pathway. Mol Med Rep 2021; 23: 397.
