eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2022
vol. 73
 
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abstract:
Case report

Early transformation event from follicular lymphoma: our experience of four cases

Anurag Mehta
1
,
Diksha Karki
1
,
Prathyusha Gudapati
1

1.
Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India
Pol J Pathol 2022; 73 (2): 166-175
Online publish date: 2022/10/04
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Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by the acquisition of additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four such cases of FL that transformed into more aggressive B-cell non-Hodgkin lymphomas within six months of their initial diagnosis. Subsequent testing of c-myc, P53 and cyclin D1 by immunohistochemistry and fluorescence in situ hybridization was done to further analyse their role in the process of transformation.
keywords:

diffuse large B-cell lymphoma, follicular lymphoma, precursor B-lymphoblastic lymphoma, transformation

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