Effect of analgesia plus placebo on low back pain – a systematic review and meta-analysis

Mirbahram Safari; Pouyan Shojaee; Shahram Shokohi; Shayan Shojaee; Vahid Banei

doi:10.5114/.2025.155988

eISSN: 2084-9850
ISSN: 1897-3116

Pielęgniarstwo Chirurgiczne i Angiologiczne/Surgical and Vascular Nursing

Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Standardy etyczne i procedury

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Effect of analgesia plus placebo on low back pain – a systematic review and meta-analysis

Mirbahram Safari

¹

,

Pouyan Shabani Shojaee

¹

,

Shahram Shokohi

²

,

Shayan Shabani Shojaee

³

,

Vahid Banei

⁴

Department of Orthopedic Surgery, Urmia University of Medical Sciences, Urmia, Iran
Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran
Resident of the Cardiology, Tabriz University of Medical Sciences, Tabriz, Iran
General Practitioner, Urmia University of Medical Sciences, Urmia, Iran

DOI: https://doi.org/10.5114/.2025.155988

Data publikacji online: 2025/11/05

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In the present study, the effect of analgesia plus placebo on low back pain was investigated. The researchers of the current study searched for key words associated with its goals in the international databases Scopus, Cochrane, Embase, and MEDLINE (PubMed) for January 2014 – December 2024 using 95% CI effect size using inverse-variance techniques and a fixed-effects model. Stata was used for the meta-analysis (version 17). The meta-analysis showed that use of medication plus placebo can reduce low back pain by 84% [ES 0.84 (–0.25, 1.92), I2 = 0%]. In conclusion, when compared to medication plus placebo, adding Diclofenac, Tramadol, Tizanidine, Aceclofenac, Thiocolchicoside, Naproxen, Metaxalone, Baclofen, and Ibuprofen does not improve functioning or pain for acute low back pain.

Effect of analgesia plus placebo on low back pain – a systematic review and meta-analysis

Mirbahram Safari 1 , Pouyan Shabani Shojaee 1 , Shahram Shokohi 2 , Shayan Shabani Shojaee 3 , Vahid Banei 4

Mirbahram Safari

¹

,

Pouyan Shabani Shojaee

¹

,

Shahram Shokohi

²

,

Shayan Shabani Shojaee

³

,

Vahid Banei

⁴