eISSN: 2299-551X
ISSN: 0011-4553
Journal of Stomatology
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vol. 76
Original paper

Effectiveness of four home oral care products for primary enamel re-mineralization with early carious lesion: an in-vitro study

Faranak Razmjouei
Mahtab Memarpour
Farshid Fathi

Oral and Dental Disease Research Center, Department of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
Student Research Committee, Department of Pediatric Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
J Stoma 2023; 76, 2: 77-83
Online publish date: 2023/06/26
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Management of dental caries during early stages is considered a clinical problem in young children.

The current in-vitro study assessed the influence of four home oral care products on re-mineralization of early caries lesions using enamel micro-hardness (EMH) test and morphological changes with scanning electron microscopy (SEM).

Material and methods
Sixty primary canine teeth were selected and randomly divided into 5 groups (n = 12 in each group). Samples were de-mineralized, and toothpaste slurries were prepared to treat de-mineralized enamel with a pH-cycling model. The groups were divided as follows: Group 1. Control (no intervention); Group 2. Fluo­ridated toothpaste; Group 3. Tooth mousse containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP); Group 4. Toothpaste containing bio-active glass and fluoride; Group 5. Tooth cream containing nano-hydroxyapatite, fluoride, and xylitol. EMH was evaluated in fifty specimens (each group, n = 10) at three times: before and after de-mineralization, and after 28 days of pH-cycling and treatment. Two samples from each group were observed with scanning electron microscopy (SEM). Data were analyzed with multiple-sample repeated measures ANOVA and Tukey’s HSD post-hoc tests (p < 0.05).

There was a significant difference in EMH between mean baseline values and de-mineralized enamel (p < 0.001). Re-mineralization significantly increased EMH in all treatment groups (p < 0.001). In group 5, the percent of EMH recovery was significantly greater than in other groups (p < 0.001). There were significant differences among the other three treatment groups (all p < 0.001). SEM images showed minerals deposited on the dissolved prismatic enamel in all groups.

The nano-hydroxyapatite-based tooth cream was the most effective home oral care product for re-mineralization of primary tooth enamel.


bio-active glass, casein phosphopeptide-amorphous calcium phosphate, dental caries, fluoride, nano-hydroxyapatite, primary enamel, re-mineralization

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