eISSN: 2299-0054
ISSN: 1895-4588
Videosurgery and Other Miniinvasive Techniques
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4/2020
vol. 15
 
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abstract:
Original paper

Effects of pneumoperitoneum with carbon dioxide on renal and hepatic functions in rats

Tayfun Bilgic
1
,
Fehmi Narter
2

1.
Department of General Surgery, Acibadem Kadikoy Hospital, Istanbul, Turkey
2.
Department of Urology, Acibadem Mehmet Ali Aydinlar University, Kadikoy Hospital, Istanbul, Turkey
Videosurgery Miniinv 2020; 15 (4): 574–582
Online publish date: 2020/03/27
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Introduction
Laparoscopic surgery is a preferred method based on its many benefits. However, increasing abdominal pressure by CO2 insufflation during the implementation of this technique poses challenges.

Aim
To determine the degree of renal and liver injury that occurs in a pneumoperitoneum (PP) model of prolonged CO2 insufflation.

Material and methods
Twenty-one female Sprague Dawley rats were separated randomly into three groups. Group 1 was the control group and given anesthesia for 3 h. In group 2, PP was administered under anesthesia for 1 h. In the last group, PP was administered under anesthesia to animals for 3 h. We measured renal and liver injury biomarkers and made a histopathological evaluation to estimate the degree of injury and assessed the correlation of biomarkers including kidney injury molecule-1 (KIM-1) with histopathological findings.

Results
Histopathological analysis according to the kidney ischemia tubular damage score showed a statistically significant difference between the 3 groups (p < 0.001). There was an increase in KIM-1 levels in the groups, although it was not statistically significant (p = 0.062, p = 0.156, p = 0.350 respectively). According to the correlation test in this research, KIM-1 results had a statistically significant association with creatinine, urea, aspartate aminotransferase and alanine aminotransferase levels in all control and study groups.

Conclusions
According to our results, the increase in KIM-1 was correlated with Cr levels and compatible with histopathological analysis. Moreover, intra-abdominal pressure statistically significantly increased the degree of kidney injury and there was not a significant increase in the levels of KIM-1. There was no difference in liver damage between groups.

keywords:

liver, pneumoperitoneum, kidney, injury, kidney injury molecule-1

  
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