eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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1/2012
vol. 63
 
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abstract:

Expression of selected neuropeptides in pathogenesis of bullous pemphigoid and dermatitis herpetiformis

Anna Cynkier
,
Agnieszka Żebrowska
,
Małgorzata Wągrowska-Danilewicz
,
Marian Danilewicz
,
Anna Erkiert-Polguj
,
Olga Stasikowska-Kanicka
,
Anna Sysa-Jędrzejowska
,
Elżbieta Waszczykowska

Pol J Pathol 2012; 1: 31-39
Online publish date: 2012/04/24
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Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expression of selected neuropeptides – CRF (corticotropin releasing factor), CGRP (calcitonin gene-related peptide), NKB (neurokinin B), SP (substance P) and the receptor for endothelin B (ETRB) – in the skin of patients suffering from BP or DH. A significantly increased expression of CRF was found in the specimen collected from the skin lesions of patients with BP and DH as well as a significantly increased expression of receptor for endothelin B in the patients with DH by the immunohistochemical method. The results obtained give evidence of a possible participation of CRF and receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis as well as CRF in bullous pemphigoid.
keywords:

bullous pemphigoid (BP), dermatitis herpetiformis (DH), neuropeptides

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