Extramammary Paget disease of the vulva treated with imiquimod

Krzysztof Sadko; Anna Płaszczyńska; Justyna Czarny

doi:10.5114/dr.2022.125686

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2022
vol. 109

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abstract:

Case report

Extramammary Paget disease of the vulva treated with imiquimod

Krzysztof G. Sadko

^{1, 2}

,

Anna Płaszczyńska

¹

,

Justyna Czarny

¹

Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland; Klinika Dermatologii, Wenerologii i Alergologii, Wydział Lekarski, Gdański Uniwersytet Medyczny, Gdańsk, Polska
Department of Adult Psychiatry, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland; Klinika Psychiatrii Dorosłych, Wydział Lekarski, Gdański Uniwersytet Medyczny, Gdańsk, Polska

Dermatol Rev/Przegl Dermatol 2022, 109, 368-376

DOI: https://doi.org/10.5114/dr.2022.125686

Online publish date: 2023/03/16

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Introduction:
Extramammary Paget disease of the vulva is a rare, malignant skin neoplasm that typically develops in postmenopausal Caucasian women.

Case report:
A 70-year-old women reported to the Dermatology Outpatient Clinic with a history of extramammary Paget disease of the vulva, with positive margins after vulvectomy. Considering non-resectability of the lesion, a decision was made to use imiquimod in local therapy on the remaining extramammary Paget disease foci, clinically corresponding to the areas of whitening within the vulva. After 3 months of local therapy, clinical improvement was achieved, and 10 months after the end of treatment, remission was confirmed in histopathological examination based on biopsy.

Conclusions:
Surgical excision of lesions remains the standard procedure in extramammary Paget disease. Subsequent treatment with imiquimod appears to be beneficial in cases of positive excision margins, to avoid further, mutilating surgery.

keywords:

Extramammary Paget disease of the vulva treated with imiquimod

Krzysztof G. Sadko 1, 2 , Anna Płaszczyńska 1 , Justyna Czarny 1

topical treatment, extramammary Paget disease, imiquimod

Krzysztof G. Sadko

^{1, 2}

,

Anna Płaszczyńska

¹

,

Justyna Czarny

¹