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Advances in Dermatology and Allergology
eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2025
vol. 42
 
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abstract:
Original paper

Flow mediated skin fluorescence to assess microcirculation in patients with atopic dermatitis

Jowita Sroka-Tomaszewska
1
,
Marcin Hellmann
2
,
Jacek Wolf
3
,
Aleksandra Michnowska
2
,
Krzysztof Narkiewicz
3
,
Magdalena Trzeciak
1

  1. Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland
  2. Division of Cardiac Diagnostics, Medical University of Gdansk, Poland
  3. Centre of Translational Medicine, Medical University of Gdansk, Poland
Adv Dermatol Allergol 2025; XLII (3): 298-305
DOI: https://doi.org/10.5114/ada.2025.149085
Online publish date: 2025/06/27
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Introduction:
Atopic dermatitis (AD) is a chronic, inflammatory skin disease with severe itching. Particular attention is dedicated to the coexistence of AD with diseases of the cardiovascular system. Since the earliest manifestation of cardiovascular disease is microvascular endothelium dysfunction, an attempt was made to assess the skin microcirculation.

Aim:
The work aims to analyse the assessment of skin microcirculation in patients with atopic dermatitis based on changes of nicotinamide adenine dinucleotide (NADH) fluorescence from the epidermis of the forearm measured with the flow mediated skin fluorescence (FMSF) technique.

Material and methods:
Thirteen patients with AD and eleven healthy individuals participated in the study. Changes in NADH fluorescence were measured by the FMSF technique on the forearm in response to blockage and release of blood flow. Results are presented as a maximum ischemic response (IRmax and IRindex,), hyperaemic response (HRmax and HRindex) or hypoxia sensitivity (HS).

Results:
The analysed FMSF parameters: IRmax, IRindex, HRmax and HRindex, HS were not significantly lower in AD patients compared with the control group. There was no association between disease severity and NADH fluorescence.

Conclusions:
The association of AD with cardiovascular disease is multifactorial. The basis of these connections is still being investigated. Microvascular endothelial dysfunction may be one but not the only mechanism responsible for the increased cardiovascular risk in patients with AD.

keywords:

atopic dermatitis, microvascular dysfunction, microcirculation
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