eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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4/2015
vol. 11
 
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Case report

Fulminant heart failure due to giant cell myocarditis affecting the left ventricle

Tomasz Senderek
,
Barbara Małecka
,
Andrzej Ząbek
,
Lucyna Rudnicka-Sosin
,
Karol Wierzbicki
,
Piotr Przybyłowski
,
Jacek Bednarek
,
Jacek Lelakowski

Postep Kardiol Inter 2015; 11, 4 (42): 351–353
Online publish date: 2015/12/01
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- fulminant heart.pdf  [0.66 MB]
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Case report

A 56-year-old woman, previously healthy, was hospitalized after an episode of ventricular tachycardia (VT) in the course of infection manifested by weakness and cough. The transthoracic echocardiography (TTE) showed reduced left ventricular ejection fraction (LVEF) to 40%. Laboratory tests indicated changed parameters of inflammation (leukocytosis 12.27 × 103/µl), levels of brain natriuretic peptide (NT-proBNP) elevated to 6241 pg/ml, and a lower level of potassium (3.2 mmol/l).
Seventy-two hours after hospitalization, diagnostics of acute coronary syndrome due to persistent elevated levels of troponin to 0.54 (ng/ml) was performed. Coronarography showed no changes in the coronary arteries but further reduction of LVEF to 15%.
The diagnostic algorithm and therapeutic options in heart failure were taken into consideration [1].
Tachyarrhythmic cardiomyopathy in the course of recurrent atrial fibrillation with a fast (up to 180/min) ventricular rate and episodes of non-sustained VT was suspected (Figures 1, 2). Because of the ineffectiveness of pharmacotherapy, it was decided to perform ablation of the AV node preceded by implantation of a pacing system. During the VVI pacemaker implantation procedure there were problems in obtaining proper pacing and sensing parameters. Ultimately the septal right ventricular outflow tract was chosen for the endocardial lead location.
A day after surgery the patient twice underwent cardiac arrest in the course of ventricular fibrillation. Gradual deterioration of electrical parameters of cardiac pacing and further reduction of LVEF to 5–10% were noted. NT-proBNP increased to 11113 pg/ml with normal levels of procalcitonin and the negative results of tests for Lyme disease and enterovirus. In view of the fulminant course of heart failure the patient was connected to an extracorporeal membrane oxygenation (ECMO) system. The biopsy of the right ventricular muscle showed no inflammatory lesions [2]. After 3 weeks of treatment with ECMO the patient received a heart transplant. A histopathological examination of the tissues of the explanted heart revealed giant cell myocarditis with areas of cardiomyocyte necrosis and formation of fibrous scar limited to the walls of the left ventricle and the interventricular septum (Figure 3). The patient was treated with immunosuppression based on induction therapy followed by a standard regimen with steroids. Currently, the patient remains in good general condition with an LVEF of 60%. All protocolar biopsies showed no signs of rejection or other histological abnormalities including recurrence of myocarditis.

Discussion

Giant cell myocarditis is a rare disease with a poor prognosis [3, 4]. It leads to progressive congestive heart failure, with ventricular arrhythmias not treatable by pharmacology or ablation. Some patients have symptoms resembling acute myocardial infarction or complete heart block. The diagnosis is made on the basis of the histological image.
In that case the heart biopsy should be taken earlier, although it is not always crucial. Due to a lack of strong signs of inflammation or any other reason explaining the fulminant course, the wrong diagnosis of tachyarrhythmic cardiomyopathy was made. It was followed by first-step treatment with implantation of a pacemaker. During that surgery electrical parameters in the septum were not fully proper because of giant cells in the left ventricle and septum. In the case of lack of a left ventricle assist device (LVAD) only ECMO before heart transplantation can help.
Ninety percent of patients die within a few weeks or have a heart transplantation, which is the best chance to save the patient’s life. The disease process develops in around 30% of grafted hearts and it can be stopped by immunosuppressants including steroids.

Conflict of interest

The authors declare no conflict of interest.

References

1. Gajos G. Diagnostic algorithm and therapeutic options in chronic heart failure: updated review of clinical practice guidelines. Pol Arch Med Wewn 2008; 118: 489-500.
2. Luk A, Metawee M, Ahm E, et al. Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy. Can J Cardiol 2009; 25: e48-54.
3. Cooper LT Jr, Berry GJ, Shabetai R. Idiopathic giant-cell myocarditis – natural history and treatment. N Engl J Med 1997; 336: 1860-6.
4. Suzuki J, Ogawa M, Watanabe R, et al. Autoimmune giant cell myocarditis: clinical characteristics, experimental models and future treatments. Expert Opin Ther Targets 2011; 15: 1163-72.
Copyright: © 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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