Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
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4/2022
vol. 39
 
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abstract:
Original paper

Genetic profile of sports climbing athletes from three different ethnicities

Mika Saito
1
,
Michał Ginszt
2
,
Ekaterina A. Semenova
3, 4
,
Myosotis Massidda
5, 6
,
Kinga Huminska-Lisowska
7
,
Monika Michałowska-Sawczyn
7
,
Hiroki Homma
1
,
Paweł Cięszczyk
7
,
Takanobu Okamoto
1
,
Andrey K. Larin
3
,
Edward V. Generozov
3
,
Piotr Majcher
2
,
Koichi Nakazato
1
,
Ildus I. Ahmetov
3, 8, 9, 10
,
Naoki Kikuchi
1

1.
Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan
2.
Department of Rehabilitation and Physiotherapy, Medical University of Lublin, Poland
3.
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia
4.
Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, Kazan, Russia
5.
Department of Life and Environmental Sciences, University of Cagliari, Italy
6.
Faculty of Medicine and Surgery, Graduate School of Exercise and Sports Sciences, University of Cagliari, Cagliari, Italy
7.
Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland
8.
Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia
9.
Laboratory of Molecular Genetics, Kazan State Medical University, Kazan, Russia
10.
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
Biol Sport. 2022;39(4):913–919
Online publish date: 2021/11/10
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This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the metaanalysis on three cohorts showed that the frequency of XX+RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities.
keywords:

sports climbing, polymorphism, ACTN3, ACE, CKM, TRHR

 
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