eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
2/2020
vol. 6
 
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abstract:
Original paper

How frequent is sleep-disordered breathing among Egyptian cirrhotic adults?

Nahla Elgammal
1
,
Tarik I Zaher
1
,
Hoida Elkomy
2
,
Ahmed Attia Abdelmoaty
1
,
Mohamed Abdallah
1
,
Mohamed H Emara
3

1.
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2.
Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3.
Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Kafrelshiekh University, Kafr Elshikh, Egypt
Clin Exp HEPATOL 2020; 6, 2: 150–157
Online publish date: 2020/06/10
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Aim of the study
Liver cirrhosis is an irreversible destructive liver disease that is associated with a wide range of complications. Among the recognized comorbidities of liver cirrhosis are sleep-disordered breathing (SDB), which is being more and more often described among cirrhotics. This study aimed to detect the prevalence of SDB among Egyptian post-viral cirrhotic adults.

Material and methods
This study enrolled 48 post-viral cirrhotic patients and 16 apparently healthy control subjects. All patients and controls were evaluated by thorough history taking, full clinical examination, laboratory investigations, the Epworth Sleepiness Scale questionnaire, the Berlin Questionnaire and polysomnography.

Results
Patients and controls were comparable as regards baseline demographics. Patients with liver cirrhosis had higher frequency of SDB compared to controls (56.2% vs. 12.5%, p = 0.002). The most frequently encountered SBD patterns among cirrhotics were obstructive sleep apnea and apnea hypopnea index. Moreover, SDB was more severe among cirrhotics (25% were mild, 16.6% were moderate and 14.6% were severe obstructive sleep apnea – OSA) compared to the healthy controls (all were mild).

Conclusions
It seems that post-viral cirrhotic patients had a wide range of SDB with variable degrees of severity compared to the healthy controls.

keywords:

sleep-disordered breathing, cirrhosis, obstructive sleep apnea, polysomnography

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