eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
vol. 17
Image in intervention

Hybrid treatment of massive pulmonary embolism by catheter-directed and surgical embolectomy

Arkadiusz Pietrasik
Aleksandra Gąsecka
Mateusz Leśniewski
Dariusz Zieliński
Szymon Darocha
Marcin Kurzyna

1st Chair and Department of Cardiology, Medical University of Warsaw, Warsaw, Poland
Department of Cardiac Surgery, Medicover Hospital, Warsaw, Poland
Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre Otwock, Poland
Adv Interv Cardiol 2021; 17, 2 (64): 236–238
Online publish date: 2021/07/09
Article file
- hybrid treatment.pdf  [0.12 MB]
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero
Pulmonary embolism (PE) is a life-threatening disease, responsible for up to 300 000 deaths annually in the US, ranking among the leading causes of cardiovascular mortality [1]. Systemic thrombolytic therapy is recommended for patients with high-risk PE [2]. Yet, thrombolysis is contraindicated or has failed in numerous patients. Surgical or percutaneous catheter-directed therapies are alternative treatment options. We present a case of massive pulmonary embolism in a patient with high-risk PE, visualized during pulmonary angiography and extracted en bloc by surgical embolectomy.
A 53-year-old woman with a history of subarachnoid hemorrhage 30 days earlier was admitted to the Intensive Cardiac Care unit with high-risk PE (Pulmonary Embolism Severity Index class IV). The patient was consulted within the local Pulmonary Embolism Response Team (PERT) – regarding progressive hemodynamical deterioration, high risk of death and the absolute contraindication to systemic thrombolysis, the patient was referred for immediate percutaneous catheter-based intervention. Since no persistent bleeding was seen on the control head computed tomography, the consulting neurosurgeon supported the proposed interventional treatment.
In the catheterization laboratory, the patient presented with tachycardia of 120 beats/min, invasively measured aortic pressure (AoP) 91/53 mm Hg (mean: 65 mm Hg) and pulmonary arterial pressure (PAP) 50/22 mm Hg (mean: 31 mm Hg). Pulmonary angiography demonstrated free-floating thrombi located in the proximal part and in all segmental branches of the right pulmonary artery, and within the inferior lobe branches on the left side (Figures 1 A, B). Percutaneous thrombectomy using the Cleaner XT Rotational Thrombectomy System was performed in the proximal part of the right pulmonary artery. Due to suboptimal results of rotational defragmentation, thrombi were additionally aspired using the Indigo System 8F Penumbra (Figure 1 C). The percutaneous procedure allowed for transient hemodynamic stabilization, as indicated by the heart rate of 90 beats/min, AoP 126/82 mm Hg (mean: 95 mm Hg) and PAP 46/19 mm Hg (mean: 28 mm Hg). However, the clinical result was insufficient, since the patient still required substantial inotropic support. One day later, surgical embolectomy was performed, enabling extraction of fresh thrombus and well-organized thrombotic lesions from both right and left pulmonary arteries (Figure 1 D), resulting in a further decrease in PAP to 25/13 mm Hg (mean: 17 mm Hg). The thrombi extracted from the right pulmonary artery were fragmented due to the preceding mechanical thrombectomy, whereas the thrombi from the left pulmonary artery were removed en bloc.
The follow-up echocardiography performed a week later demonstrated normal left ventricle function and no right ventricle overload. Following the in-hospital rehabilitation, the patient presented with only mild cognitive dysfunction and was mobile, if assisted. Surgical embolectomy is the preferred form of treatment in patients with PE and contraindications to systemic thrombolysis due to the possibility of en bloc removal of the thrombi and favorable results in the recent trials [2]. However, patients with extensive proximal thrombi may require combined percutaneous and surgical treatment [3]. In our patient, the organized and fibrotic thrombi removed en bloc might suggest that the acute PE was overlapping with the pre-existing chronic thromboembolic lesions. Well-organized, real-time communication within the local PERT is crucial to enhance decision-making and facilitate immediate treatment [4].

Conflict of interest

The authors declare no conflict of interest.


1. Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects. Circ Res 2016; 118: 1340-7.
2. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J 2020; 41: 543-603.
3. Kurzyna M, Pietrasik A, Opolski G, Torbicki A. Contemporary methods for the treatment of pulmonary embolism – is it prime-time for percutaneous interventions? Kardiol Pol 2017; 75: 1161-70.
4. Dudzinski DM, Piazza G. Multidisciplinary pulmonary embolism response teams. Circulation 2016; 133: 98-103.
Copyright: © 2021 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe