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Contemporary Oncology/Współczesna Onkologia
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vol. 22
Short communication

Identification of catheter misplacement in early port CVC dysfunction

Davide Mauri, Georgia Zafeiri, Lampriani Tsali, Anastasia Chalkidou, Georgios Zarkavelis, Alexandra Papadaki, Panagiotis Filis, George Pentheroudakis

Contemp Oncol (Pozn) 2018; 22 (2): 129-134
Online publish date: 2018/06/30
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A portacath is a subcutaneously implanted central venous access device that provides an “any-time” venous access for patients with inadequate peripheral veins. Port central venous catheters (CVCs) are also implanted among patients who are in need of outpatient-based continuous administration of chemotherapy, total parenteral nutrition, or antibiotics; and in in-patient settings among patients who are in need of frequent administration of chemotherapy and blood sampling, as well as in patients with chemotherapy-induced recurrent thrombophlebitis. For these reasons the use of port central venous catheters (CVCs) has had an exponential growth over the last decades in both haematology and oncology settings. Guidelines on central venous access in oncology have been provided both by ESMO and ASCO [1, 2].
Outpatient infusion therapy with permanent indwelling port CVCs may sometimes be complicated by catheter malfunction (such as partial or total blockade), bloodstream infections, thrombosis, and pulmonary embolism [1–5].
Port CVC misplacement is an important cause of catheter malfunction and thrombosis [5, 6]. An accurate port CVC placement may indeed represent the most effective tool in minimising CVC-associated thrombotic complications [5].
Despite the fact that port-CVC misplacement is an uncommon event and its occurrence is estimated to be up to 6% [3, 7], a prospective study from Harvard Brigham and Women’s Hospital underscored that the occurrence of port CVC malposition might be up to 67% in patients with early CVC dysfunction (dysfunction occurring within three months of CVC insertions) [7].
In direct contrast with the increasing use of port CVCs and the potential harm related to CVC misplacement sequels, no educational iconographic material is currently available to assist clinicians in prompt recognition of port CVC misplacement. This in turn may result in diagnostic delay, lead to avoidable sequels, and jeopardise the patients’ safety.
Nevertheless, the delay might be further worsened in cases where physicians implanting port CVCs operate in medical centres different from the chemotherapy unit where the drugs are delivered to the patients, and oncologists/haematologists might not be experienced in evaluating port-CVC misplacement. In the Bansal study 20% of malfunctioning CVCs were inserted in different institutions than the one where the chemotherapies were delivered [6].
Thus, the aim of the present educational manuscript is to support medical oncologists, haematologists, and clinicians in prompt suspicion, recognition, and management of port-a-cath catheter misplacement among patients with early port CVC malfunction.

Where should the catheter be placed?

The insertion of an implantable port-CVC devices is generally percutaneous, either using the internal jugular vein under 2D ultrasound guidance or subclavian vein access [1]. Ideally, the catheter tip should terminate in the superior vena cava, just upstream of the right atrium (Figs. 1, 2).
The catheter tip position should be verified radiologically with an intraoperative fluoroscopy or a postoperative chest X-ray. The evaluation with postplacement radiograph results in a 50% decrease in the incidence of suboptimal positioning [6].
Early catheter malfunction is any catheter dysfunction occurring within three months of a port-CVC insertion.
Dysfunction is generally due to partial blockade (inability to flush or withdraw fluids from the port, reduced flow rate) or complete blockade (no catheter flow in any direction).

First signs and symptoms of misplacement

Generally, the first sign of catheter malfunction is difficulty in aspirating or infusing/flushing through the lumen of the catheter. The patient may complain of pain or a burning sensation during injection. In case of misplacement with the catheter tip in the internal jugular vein (leading to inverted flow with turbulence), an acute pain or disturbance in the ipsilateral ear may be reported during flushing. A loop of the catheter in the jugular vein is generally associated with a sensation of pressure, tenderness, and local pain; the presence of the catheter loop is frequently palpable through the skin during clinical examination. Arrhythmias might also occur in cases of right atrial and particularly in right ventricular positioning of the catheter tip.

How to investigate it

Firstly, it is useful to rule out minor causes of total or partial port-CVC blockade dysfunction.
• If the catheter tip blocked by catheter decubitus on the superior vena cava vessel wall, changing the patient’s posture may lead to catheter functioning.
• Postural changes of the patient may be of value even in bypassing the pinch-off syndrome (in the case of subclavian access, the catheter is compressed during its passage through the narrow angle between the first rib and the lateral position of the clavicle) and lead to catheter patency.
• Performing a single cycle of fibrinolytic therapy (intracatheter dwell with alteplase 1 mg/ml or urokinase 5000 IU/ml for 40 minutes) might be useful in unblocking central lines [8]. In the case of simple fibrin sheet or ball-valve-type clot on the tip of the catheter lumen the catheter patency will probably be restored.
Secondly, in case of malfunctioning port-catheters that do not respond to postural changes and to a single cycle of lytic therapy, catheter misplacement and thrombosis should be ruled out.
• A chest X-ray (face and profile) should be promptly obtained to evaluate possible catheter misplacement.
• A US Doppler evaluation of major venous vessels is mandatory to exclude catheter-related thrombosis.
It should be highlighted that instilling anything into a catheter that does not give a blood return, and use of pressure to overcome catheter blockade is against recommendations. Pushing fluid into a clotted catheter can dislodge a clot, causing it to travel into the lungs putting the patient at risk of pulmonary embolism.

Radiological features for port CVC misplacement

Catheter misplacement is the presence of the catheter in any position other than correct. This can be due to catheter mispositioning (catheter inserted in any position other than correct), catheter migration (catheters correctly placed but successively migrated to an incorrect position), or catheter fracture (catheter breakage). To ease the prompt recognition of port CVC misplacement among patients with early CVC dysfunction, we provide a photographic review of radiologic pathological features. The aim is to speed up diagnosis and to help clinicians to become familiar with different pathological radiological conditions.
Common radiological features of CVC catheter misplacement are provided below.
• Catheter compressed during its passage through the narrow angle between the first rib and the lateral position of the clavicle, resulting in pinch-off syndrome (Fig. 3).
• Catheter mispositioning in the inferior vena cava (Fig. 4). These patients generally report an extremely laborious and difficult positioning of the catheter with associated palpitation, tachycardia, arrhythmias, and sensation of sudden death during the catheter insertion procedure.
• Catheter loop in the venous lumen (Figs. 5, 6). Loop in vein lumen results in flow turbulence and thrombosis.
• Catheter migration in the contralateral subclavian vein (Fig. 7).
• Catheter tip in the ipsilateral jugular vein (Fig. 8).
• Tight suture (Figs. 9, 10).
• Catheter length with endocardial loop in the right atrium (Fig. 11). Palpitation, tachycardia, arrhythmias may occur during the catheter insertion procedure.
• Catheter fracture (Figs. 12, 13).
• Catheter shortness (Figs. 14, 15).
• Narrow angle loop before entering the subclavian vein (Figs. 16, 17).
• Catheter kinking: a catheter tight curl, twist, or bend from any cause and at any site of the catheter, causing its malfunction. In the reported figures kinks are due to pinch-off syndrome, tight sutures, or narrow angle loops (Figs. 3, 9, 10, 16, 17).
If any port CVC misplacement is recognised (mispositioning, migration fracture, kinking, etc.), the patient should immediately be forwarded to an interventional radiology department for correction, repositioning, or removal. A list of possible corrections is listed in the flow chart (Fig. 18).
In case of co-presence of thrombosis, a short course (3–5 days) of anticoagulation therapy is recommended before managing or removing the catheter, in order to avoid clot embolism [1].
Of note, many port CVCs are accidentally inserted with the catheter tip in the right atrium. In this case, if the catheter is functioning and it is not complicated by blockage, thrombosis, infections, or arrhythmias, the device can be maintained and used without repositioning or removal.


Early malfunction of port CVCs is strongly associated with port catheter misplacement. Considering the potential harm related to CVC misplacement sequels, patients with malfunction of their indwelling port CVCs, who do not respond to a single cycle of fibrinolytic therapy, should undergo prompt radiological evaluation of catheter position and U/S 2D Doppler evaluation of major vessels.

The authors declare no conflict of interest.


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Address for correspondence

Davide Mauri
University Hospital of Ioannina
Leof. Stavrou Niarchou 45500 Ioannina, Greece
e-mail: dvd.mauri@gmail.com

Submitted: 22.01.2018
Accepted: 24.03.2018
Copyright: © 2018 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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