eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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1A/2015
 
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abstract:

Review
Epigenetic mechanisms of induced pluripotency

Marta Gładych
,
Anastazja Andrzejewska
,
Urszula Oleksiewicz
,
Marcos R.H. Estécio

Contemp Oncol (Pozn) 2015; 19 (1A): A30–A38
DOI: https://doi.org/10.5114/wo.2014.47135
Online publish date: 2015/01/20
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Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.
keywords:

induced pluripotent stem cells, epigenetics, chromatin modifications, DNA methylation
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