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ISSN: 1233-9687
Polish Journal of Pathology
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3/2016
vol. 67
 
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abstract:
Original paper

Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma

Piotr Czapiewski
1, 2
,
Maciej Bobowicz
3
,
Rafał Pęksa
1
,
Marcin Skrzypski
4
,
Adam Gorczyński
1
,
Kamila Szczepańska-Michalska
5
,
Aleksandra Korwat
5
,
Michał Jankowski
6
,
Wojciech Zegarski
6
,
Anna Szulgo-Paczkowska
7
,
Tomasz Polec
3
,
Michał Piątek
8
,
Jarosław Skokowski
3
,
Johannes Haybaeck
2, 9
,
Anna Żaczek
10
,
Wojciech Biernat
1

1.
Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland
2.
Department of Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
3.
Department of Oncological Surgery, Medical University of Gdańsk, Gdańsk, Poland
4.
Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland
5.
Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland
6.
Chair of Oncological Surgery, Collegium Medicum, Nicolaus Copernicus University; Oncology Centre, Bydgoszcz, Poland
7.
Department of Clinical Oncology, Centre of Oncology, Bydgoszcz, Poland
8.
Department of Clinical Oncology of the University Clinical Centre, Silesian Medical University, Katowice, Poland
9.
Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
10.
Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
Pol J Pathol 2016; 67 (3): 228-234
DOI: https://doi.org/10.5114/pjp.2016.63774
Online publish date: 2016/11/25
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Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN–, 85 cases).

Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.

K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.

We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
keywords:

keratin 7, metastasis, colon carcinoma, prognosis, lymph node metastases
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