Abstract
3/2016
vol. 67
Original paper
Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma
- Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland
- Department of Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
- Department of Oncological Surgery, Medical University of Gdańsk, Gdańsk, Poland
- Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland
- Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland
- Chair of Oncological Surgery, Collegium Medicum, Nicolaus Copernicus University; Oncology Centre, Bydgoszcz, Poland
- Department of Clinical Oncology, Centre of Oncology, Bydgoszcz, Poland
- Department of Clinical Oncology of the University Clinical Centre, Silesian Medical University, Katowice, Poland
- Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
- Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland
Pol J Pathol 2016; 67 (3): 228-234
Online publish date: 2016/11/25
Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN–, 85 cases).
Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.
K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.
We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.
K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.
We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
Keywords
keratin 7, metastasis, colon carcinoma, prognosis, lymph node metastases
Integrated with
