eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
3/2016
vol. 67
 
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abstract:
Original paper

Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma

Piotr Czapiewski
,
Maciej Bobowicz
,
Rafał Pęksa
,
Marcin Skrzypski
,
Adam Gorczyński
,
Kamila Szczepańska-Michalska
,
Aleksandra Korwat
,
Michał Jankowski
,
Wojciech Zegarski
,
Anna Szulgo-Paczkowska
,
Tomasz Polec
,
Michał Piątek
,
Jarosław Skokowski
,
Johannes Haybaeck
,
Anna Żaczek
,
Wojciech Biernat

Pol J Pathol 2016; 67 (3): 228-234
Online publish date: 2016/11/25
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Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN–, 85 cases).

Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.

K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.

We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.
keywords:

keratin 7, metastasis, colon carcinoma, prognosis, lymph node metastases

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