eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2021
vol. 38
 
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abstract:
Original paper

Lipid profile disturbances may predispose psoriatic patients to liver dysfunction

Dorota Kozłowska
1
,
Ewa Harasim-Symbor
2
,
Hanna Myśliwiec
1
,
Anna J. Milewska
3
,
Adrian Chabowski
2
,
Iwona Flisiak
1

1.
Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland
2.
Department of Physiology, Medical University of Bialystok, Bialystok, Poland
3.
Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland
Adv Dermatol Allergol 2021; XXXVIII (2): 310-318
Online publish date: 2021/05/22
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Introduction
Psoriasis is a chronic inflammatory disease associated with metabolic disturbances and liver dysfunction. Both serum fatty acids (FA) and ceramides (Cer) have structural functions but also are signal molecules that could be involved in the pathogenesis of liver dysfunction.

Aim
To assess the concentration of the circulating FA and Cer in correlation with the alanine aminotransferase (ALT) blood level in psoriatic patients. In addition, we have examined the relationship between ALT concentration and severity of the disease and inflammation markers.

Material and methods
Eighty-five patients with psoriasis and 32 healthy controls were enrolled in the study. Patients were divided into 2 groups according to ALT blood levels. Serum concentration of 14 FA and 14 Cer were measured by gas-liquid chromatography. The results were correlated with the Psoriasis Area and Severity Index (PASI), serum lipid profile, and inflammatory markers.

Results
We observed higher PASI score (p = 0.01) and higher C-reactive protein (p = 0.02) concentration in the group of psoriatic patients with high ALT. Serum ALT positively correlated with saturated fatty acids (SFA) (p = 0.01, r = 0.27) and SFA/unsaturated fatty acids (UFA) ratio (p = 0.01, r = 0.26). ALT negatively correlated with UFA level (p = 0.008, r = –0.28). Lignoceric ceramide positively correlated with ALT level (r = 0.22; p = 0.045) in psoriatic patients.

Conclusions
Patients with severe psoriasis are predisposed to the development of liver dysfunction. We have demonstrated disturbances of serum fatty acid and sphingolipid profile in psoriatic patients, which may trigger liver disease.

keywords:

psoriasis, ceramide, fatty acid, liver disease

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