eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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vol. 16
Letter to the Editor

Long-term follow-up after surgical removal of thymolipoma

Mahnaz Amini
Seyed Hossein Fattahi Masuom
Asieh Sadat Fattahi

Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Kardiochir Torakochir Pol 2019; 16 (4): 206-208
Online publish date: 2020/01/15
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The thymus is the largest lymphoid tissue of the human body, located in the superior mediastinum, growing until puberty and then involuting to nearly disappear around 18 years [1]. It can be affected by benign and malignant neoplasms. Thymolipoma, comprising 2–9% of thymic neoplasms, is a rare benign neoplasm of the thymus composed of mature adipose and thymic tissue [1]. Less than 200 cases had been reported in the literature by 2015 [2]. Although rare, it should be considered in the differential diagnosis for any anterior mediastinal mass with fat density.
A 22-year-old man was admitted to Ghaem teaching hospital, Mashhad, Iran with 3 months history of dyspnea on exertion and chest heaviness. He had no other chest, constitutional symptoms or signs of autoimmune disorders. On physical examination the only abnormal finding was complete absence of vesicular breath sounds in the left hemithorax. Posteroanterior chest radiograph revealed a huge fat density obscuring the left heart and mediastinal border (Figure 1).
Chest computed tomography (CT) showed a large mass (22 × 19 × 17 cm) with fat density admixed with soft tissue strands occupying the anterosuperior mediastinum extending to the left hemithorax (Figure 2). Laboratory tests were not remarkable. The patient was scheduled for surgical resection with a primary diagnosis of thymolipoma. Care was taken as regards malacia or external pressure of the left main bronchus. Partial sternotomy was accompanied with left thoracotomy through the fifth left intercostals space. The tumor (31 × 15 × 12 cm) resided left of the pericardium without any invasion to pericardial or lung tissue (Figure 3).Dehiscence of the tumor by blunt and sharp dissection was easily done with care about preservation of the left phrenic nerve.
A large encapsulated tumor with a yellowish elastic surface and soft yellowish fatty tissue by incision was removed (Figure 4). Histopathological examination revealed mature adipose tissue and hyperplastic thymic structures with Hassel’s corpuscles identified as a benign thymolipoma.
The postoperative period was uneventful, and the patient was discharged on the 5th postoperative day with good general condition. Frequent yearly visits until 10 years showed no symptom or sign of recurrence or any clue in favor of autoimmune disorders.
Lange reported the first case of thymolipoma in 1612, but the term of thymolipoma was used many years later by Eid et al. in 2017 [3]. Thymolipoma is a rare benign neoplasm of the thymus of unknown etiology representing 2–9% of thymic neoplasms with no known predilection to specific age or sex.
Many different pathogenic mechanisms have been proposed for thymolipoma [4], from replacement of the thymus with mature adipose tissue, involuting thymic hyperplasia, mixed tumor theory and involuting thymoma theory. Thymolipoma shows a slow insidious growth with most of the reported cases presenting as huge masse before diagnosis.
Patients are usually asymptomatic, but most patients complain of vague symptoms in the chest because of compression of fatty tissue on adjacent structures including the heart, the great vessels, the lungs or the bronchi [5] with reports of respiratory distress or failure [6, 7]. They can be even incidentally found and misdiagnosed as a large cardiac silhouette in chest radiograph [8].
As in the case of thymoma, thymolipoma can present with some autoimmune disorders such as myasthenia gravis, systemic lupus erythematosus, hypogammaglobulinemia, Graves’ disease and red cell aplasia (RCA) [9]. Huang et al. studied 267 patients with MG who underwent extended thymectomy, with 12 (4.4%) patients showing thymolipoma in the pathologic study. Compared with myasthenic thymoma, myasthenic thymolipoma had longer preoperative duration of symptoms and larger mass. Compared with non-myasthenic thymolipoma patients, myasthenic thymolipoma patients were older with smaller masses which were diagnosed after surgery [10].
Characteristic CT findings include a usually huge mass originating from or connected to the thymus gland with fatty tissue and soft tissue strands as islands of normal thymic components [11]. The main differential diagnoses of thymolipoma in imaging are lipoma, liposarcoma, teratoma, pericardial fat pad or diaphragmatic hernias [12]. Magnetic resonance imaging (MRI) scans are specific for high signal intensity mixed with intermediate intensity on T2-weighted images. Adipose tissue of the tumor is intense in T1-weighted images [13].
As thymolipoma is a benign neoplasm with no reported case of recurrence, its main treatment is complete surgical removal. Preoperative tissue diagnosis with biopsy is not usually needed. The surgical approach to resection of thymolipoma is through sternotomy, anterolateral thoracotomy, clamshell incision or sternotomy accompanied by anterolateral thoracotomy (hemi-clamshell incision).
The natural course of thymolipoma after surgical removal is usually uneventful [14]. Rieker et al. reported 5-year follow-up after surgical removal of thymolipoma in 9 cases. All their patients were free of symptoms 5 years after surgery [9].
To the best of our knowledge this is the first case of thymolipoma surgical treatment with 10 years’ symptom-free follow-up. Our patient had no sign of recurrence or autoimmune disorders after about one decade, emphasizing the benign nature of thymolipoma.
This is one of the longest symptom-free survival reports of thymolipoma after surgical removal with about one decade of no complaints or autoimmune symptoms. This case report emphasizes the benign nature of thymolipoma after surgical removal even after many years.


The authors report no conflict of interest.


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Copyright: © 2020 Polish Society of Cardiothoracic Surgeons (Polskie Towarzystwo KardioTorakochirurgów) and the editors of the Polish Journal of Cardio-Thoracic Surgery (Kardiochirurgia i Torakochirurgia Polska). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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