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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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5/2011
vol. 49
 
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abstract:
Review paper

Mixed connective tissue disease: 40 years of history

Marzena Olesińska
,
Anna Felis-Giemza
,
Katarzyna Walkiewicz-Pielaszek
,
Zenobia Czuszyńska

Reumatologia 2011; 49, 5: 366–371
Online publish date: 2011/09/27
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The history of mixed connective tissue disease (MCTD) started 40 years ago as a result of long-term observation of patients with features resembling systemic lupus erythematosus (SLE), scleroderma and poly- or dermatomyositis. A high titre of anti-extractable nuclear antigen antibodies (anti-ENA) in these patients was also revealed. This paper presents formation of views on clinical aspects of MCTD, development of diagnostic methods identifying antigens involved in disease initiation and modern technique appliance in defining pathogenic mechanisms (Table I). Looking at the growing knowledge on MCTD we can follow 40 years of medicine progress.
keywords:

mixed connective tissue disease, anti-U1-RNP antibodies, history




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