Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction

Michał Węgiel; Kinga Glądys; Barbara Zdzierak; Artur Dziewierz; Stanisław Bartuś; Tomasz Rakowski

doi:10.5114/aic.2025.151724

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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abstract:

Original paper

Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction

Michał Węgiel

¹

,

Kinga Glądys

²

,

Barbara Zdzierak

¹

,

Artur Dziewierz

^{1, 3}

,

Stanisław Bartuś

^{1, 3}

,

Tomasz Rakowski

^{1, 3}

Clinical Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland
Students’ Scientific Society Jagiellonian University Medical College, Krakow, Poland
2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland

Adv Interv Cardiol

DOI: https://doi.org/10.5114/aic.2025.151724

Online publish date: 2025/05/31

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AMA

Węgiel M, Glądys K, Zdzierak B, Dziewierz A, Bartuś S, Rakowski T. Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2025. doi:10.5114/aic.2025.151724.

APA

Węgiel, M., Glądys, K., Zdzierak, B., Dziewierz, A., Bartuś, S.,  & Rakowski, T. (2025). Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. https://doi.org/10.5114/aic.2025.151724

Chicago

Węgiel, Michał, Kinga Glądys, Barbara Zdzierak, Artur Dziewierz, Stanisław Bartuś,  and Tomasz Rakowski. 2025. "Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. doi:10.5114/aic.2025.151724.

Harvard

Węgiel, M., Glądys, K., Zdzierak, B., Dziewierz, A., Bartuś, S.,  and Rakowski, T. (2025). Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. https://doi.org/10.5114/aic.2025.151724

MLA

Węgiel, Michał et al. "Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 2025. doi:10.5114/aic.2025.151724.

Vancouver

Węgiel M, Glądys K, Zdzierak B, Dziewierz A, Bartuś S, Rakowski T. Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2025. doi:10.5114/aic.2025.151724.

Introduction:
Myocardial infarction (MI) is a complex clinical syndrome that significantly influences long-term outcomes through its effects on myocardial remodeling, heart failure progression, and mortality. Despite extensive research, there is still no consensus regarding optimal biomarkers for risk stratification of MI patients in terms of long-term outcomes.

Aim:
The study aimed to assess neutrophil-to-lymphocyte ratio (NLR) and evaluate the association between this ratio and long-term clinical and echocardiographic outcomes in patients hospitalized for MI.

Material and methods:
A total of 412 patients hospitalized for MI between 2016 and 2019 were screened. Demographic data, baseline clinical characteristics, typical biochemical parameters, and angiographic and echocardiographic findings were analyzed. Patients underwent long-term clinical and echocardiographic follow-up.

Results:
NLR correlated negatively with both baseline and follow-up left ventricular ejection fraction (LVEF) (r = –0.214; p = 0.043 and r = –0.3; p < 0.001, respectively). In regression analysis, NLR was a significant predictor of long-term reduced LVEF (defined as a value < 40%) (OR = 4.01; p < 0.001) as well as all-cause mortality (OR = 1.16; p = 0.008). In receiver operating characteristic (ROC) analysis, NLR demonstrated significant predictive value for mortality (AUC = 0.65; p = 0.04) with an optimal cut-off point of 8.7 (Youden index = 0.4). Kaplan-Meier analysis revealed that patients with NLR > 8.7 had significantly poorer survival compared to those with lower NLR values (p < 0.001).

Conclusions:
Elevated NLR was associated with poorer left ventricular function and increased mortality in patients after MI during long-term observation.

keywords:

Neutrophil-to-lymphocyte ratio as a predictor of left ventricle function and mortality in patients with myocardial infarction

Michał Węgiel 1 , Kinga Glądys 2 , Barbara Zdzierak 1 , Artur Dziewierz 1, 3 , Stanisław Bartuś 1, 3 , Tomasz Rakowski 1, 3

heart failure, myocardial remodeling, biomarkers

Michał Węgiel

¹

,

Kinga Glądys

²

,

Barbara Zdzierak

¹

,

Artur Dziewierz

^{1, 3}

,

Stanisław Bartuś

^{1, 3}

,

Tomasz Rakowski

^{1, 3}