eISSN: 2299-551X
ISSN: 0011-4553
Journal of Stomatology
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vol. 76
Original paper

Odontogenic keratocyst in geriatric population: a developmental cyst in elderly patients

Eman M. Abdulhady
Bacem Abdullah
Mohamed A. Tawfik

Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Horus University in Egypt, New Damietta, Egypt
Department of Maxillofacial Pathology, Mansoura University, Mansoura, Egypt
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mansoura University, Mansoura, Egypt
J Stoma 2023; 76, 2: 108-116
Online publish date: 2023/06/26
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Odontogenic keratocyst (OKC) was rarely reported in geriatric population. To the best of our knowledge, only 15 cystic cases, of which one radiograph was documented, and eight solid OKCs were reported in geriatric patients.

This study investigated the difference between the histological and immuno-histochemical profile of juvenile and geriatric cases of sporadic OKC.

Material and methods
In this retrospective study, a control group of 15 sporadic juvenile OKCs (group 1), 15 juvenile syndromic OKCs (group 2), and 15 juvenile recurrent OKCs (group 3) patients were included and clinico-pathologically compared with newly reported cases. Group 4 was composed of three geriatric cases only. Paraffin wax blocks were sectioned to be stained with anti-NPM1/ALK (Abcam), anti-CK7, anti-CK14, anti-Ki-67, anti-SOX-10, and anti-Cyclin D1 in all groups. One-way ANOVA test was used to compare the studied groups.

The difference between immuno-staining for anti-NPM1/ALK, anti-CK7, anti-CK14, anti-Ki-67, anti-SOX-10, and anti-Cyclin D1 was not statistically significant. Therefore, the nature of OKC in the geriatric population did not differ from that of the younger population, posing strong controversy about classifying OKCs as only developmental lesions.

True sporadic odontogenic keratocyst can affect geriatric populations, which defies the general theoretical consensus about the developmental origin of sporadic OKCs. This is complicated by the fact that the proliferation index is high in geriatric and juvenile populations.


cysts, geriatric OKC, immuno-histochemistry, odontogenic keratocyst

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